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引用次数: 0
摘要
多发性骨髓瘤是一种无法治愈的克隆性浆细胞恶性肿瘤。各种诊断方法并行使用,以准确确定疾病的分期和严重程度。确定一种或一组生物标志物,可以通过采用更加个性化的方法,提高患者接受医疗护理的质量。代谢组学利用高通量分析平台来检测生物样本中生化化合物的水平和数量。本综述旨在对可能有助于 MM 诊断和预后的潜在代谢生物标志物进行系统的文献检索。综述按照 PRISMA 建议进行,并在 PROSPERO 上进行了注册。在 PubMed、CINAHL、SciFinder、Scopus、The Cochrane Library 和 Google Scholar 中进行了系统检索。研究仅限于涉及临床确诊的 MM 患者和健康对照组的研究。文章必须以英语发表,对发表日期或样本类型没有限制。文章质量根据 QUADOMICS 标准进行评估。文献检索共收集到 709 篇文章。其中,436 篇文章根据其摘要被排除,另有 26 篇文章在对全文进行彻底审查后被删除。最后,有 16 篇文章被认为是相关的,并对其数据进行了进一步分析。发现了一些有希望的候选生物标志物。要确定这些生物标志物是否适合临床应用,还需要进行大样本量的后续研究。
Metabolomic biomarkers of multiple myeloma: A systematic review
Multiple myeloma (MM) is an incurable malignancy of clonal plasma cells. Various diagnostic methods are used in parallel to accurately determine stage and severity of the disease. Identifying a biomarker or a panel of biomarkers could enhance the quality of medical care that patients receive by adopting a more personalized approach. Metabolomics utilizes high-throughput analytical platforms to examine the levels and quantities of biochemical compounds in biosamples. The aim of this review was to conduct a systematic literature search for potential metabolic biomarkers that may aid in the diagnosis and prognosis of MM. The review was conducted in accordance with PRISMA recommendations and was registered in PROSPERO. The systematic search was performed in PubMed, CINAHL, SciFinder, Scopus, The Cochrane Library and Google Scholar. Studies were limited to those involving people with clinically diagnosed MM and healthy controls as comparators. Articles had to be published in English and had no restrictions on publication date or sample type. The quality of articles was assessed according to QUADOMICS criteria. A total of 709 articles were collected during the literature search. Of these, 436 were excluded based on their abstract, with 26 more removed after a thorough review of the full text. Finally, 16 articles were deemed relevant and were subjected to further analysis of their data. A number of promising candidate biomarkers was discovered. Follow-up studies with large sample sizes are needed to determine their suitability for clinical applications.
期刊介绍:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.