基于金属纳米粒子的生物传感器用于早期诊断 ESKAPE 病原体引起的传染病,应对抗菌药耐药性危机

Biosensors Pub Date : 2024-07-11 DOI:10.3390/bios14070339
Juan Carlos Gutiérrez-Santana, Viridiana Rosas-Espinosa, Evelin Martinez, Esther Casiano-García, Victor Rafael Coria-Jiménez
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引用次数: 0

摘要

ESKAPE 菌群(屎肠球菌、金黄色葡萄球菌、肺炎克雷伯氏菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属)中的菌种具有很强的抗菌药耐药性(AMR),这一健康问题已经成为导致死亡的主要原因之一,到 2050 年,每年可能导致 1 000 万人死亡。新的潜在治疗分子的产生不足以应对 AMR "危机",世界卫生组织(WHO)已表示将努力促进快速诊断策略的发展。金属纳米粒子(MNPs)的物理化学特性使人们有可能设计出能够在短期内识别低浓度 ESKAPE 细菌的生物传感器;其他系统则能识别抗菌药敏感性,有些系统还被设计成具有原位双重活性(细菌检测和抗菌活性),这表明在不久的将来,基于 MNPs 的多功能生物传感器就有可能实现商业化,能够快速识别临床壁龛中的细菌病原体。本综述重点介绍基于 MNP 的系统如何用于快速、准确地识别临床上重要的细菌病原体,并展示了为实现这些目标进行深入研究的必要性。本综述重点讨论了利用基于金属纳米粒子的系统快速准确地鉴定临床上重要的细菌病原体。
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Metal Nanoparticle-Based Biosensors for the Early Diagnosis of Infectious Diseases Caused by ESKAPE Pathogens in the Fight against the Antimicrobial-Resistance Crisis
The species included in the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and the genus Enterobacter) have a high capacity to develop antimicrobial resistance (AMR), a health problem that is already among the leading causes of death and could kill 10 million people a year by 2050. The generation of new potentially therapeutic molecules has been insufficient to combat the AMR “crisis”, and the World Health Organization (WHO) has stated that it will seek to promote the development of rapid diagnostic strategies. The physicochemical properties of metallic nanoparticles (MNPs) have made it possible to design biosensors capable of identifying low concentrations of ESKAPE bacteria in the short term; other systems identify antimicrobial susceptibility, and some have been designed with dual activity in situ (bacterial detection and antimicrobial activity), which suggests that, in the near future, multifunctional biosensors could exist based on MNPs capable of quickly identifying bacterial pathogens in clinical niches might become commercially available. This review focuses on the use of MNP-based systems for the rapid and accurate identification of clinically important bacterial pathogens, exhibiting the necessity for exhaustive research to achieve these objectives. This review focuses on the use of metal nanoparticle-based systems for the rapid and accurate identification of clinically important bacterial pathogens.
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