杯突：机制及在淋巴瘤中的应用

IF 2.3 4区医学 Q3 ONCOLOGY Current cancer drug targets Pub Date : 2024-07-11 DOI:10.2174/0115680096296742240614100116

Yubo Wang, Fengyue Yin, Quanyi Jin, Chen Liu, Zhongquan Qi, Dengyue Chen, Yiming Luo

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引用次数: 0

摘要

细胞死亡领域受到科学界越来越多的关注，并被证明是癌症发生和发展的基础。铜氧化酶是最近在 2022 年提出的一种细胞死亡方法，它不同于之前报道的任何方法。其原理是铜离子导致细胞内蛋白质的聚集和不稳定。越来越多的研究人员致力于丰富铜凋亡的机制，并探索其与癌症的关系。研究发现，细胞内的铜含量对淋巴瘤的发生和发展有影响。由于淋巴瘤的复杂性和治疗的局限性，有必要对该疾病进行深入研究。我们将回顾铜氧化机制及其在淋巴瘤治疗中的潜力。

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Cuproptosis: Mechanism and Application in Lymphoma.

The cell death field has profited from the increasing attention of the scientific community and has been shown to lie at the very basis of cancer initiation and progression. Cuproptosis is a recently proposed method of cell death in 2022, and it is different from any previously reported method. The principle is that copper ions lead to aggregation and instability of intracellular proteins. An increasing number of researchers are dedicated to enriching the mechanism of cuproptosis and exploring its relationship with cancer. Studies have found that intracellular copper levels have an impact on the occurrence and development of lymphoma. The complexity of lymphoma and the limitations of treatment necessitate in-depth studies of the disease. We will review the mechanism of cuproptosis and its potential in lymphoma therapy.

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来源期刊

Current cancer drug targets 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

105

审稿时长

1 months

期刊介绍： Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.