用于口咽部热疗的磁共振温度计。

IF 3 3区 医学 Q2 ONCOLOGY International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-07-11 DOI:10.1080/02656736.2024.2352545
Theresa V Feddersen, Juan A Hernandez-Tamames, Margarethus M Paulides, Michiel Kroesen, Gerard C van Rhoon, Dirk H J Poot
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引用次数: 0

摘要

磁共振温度测量(MRT)可实时、无创地测量体内三维温度变化。然而,对于口咽部和整个头颈部,运动可能会带来较大的伪影。考虑到治疗时间长达 60-90 分钟,本研究旨在评估口咽部周围的 MRT 在热疗中是否具有临床可行性,并量化呼吸和吞咽对 MRT 性能的影响。研究使用三维-ME-FGRE 序列对五名志愿者的口咽周围和冷却后的模型进行了长达 75 分钟的成像。成像方案包括加速成像(ARC = 2)、图像平均值(NEX = 1、2 和 3)。对于志愿者,采集包括屏气扫描和故意吞咽扫描。使用平均误差(MAE)、平均误差(ME)和空间标准偏差(SD)对颈部肌肉、脊髓和颌面肌的 MRT 性能进行量化。在模型中,NEX 的增加会导致 SD 显著减少,但 MAE 和 ME 保持不变。在志愿者中,不同扫描之间没有发现明显差异。评估区域之间存在显著差异:颈部肌肉的 MAE(=1.96 °C)和 SD(=0.82 °C)最佳,其次是脊髓(MAE=3.17 °C,SD=0.92 °C)和颌下肌(MAE=4.53 °C,SD=1.16 °C)。在ME值方面,脊髓表现最佳,然后是颈部肌肉和颌面部肌肉,分别为-0.64 °C、1.15 °C和-3.05 °C。呼吸、吞咽和不同的成像方式(加速和 NEX)对口咽区域的 MRT 性能没有显著影响。然而,所选的 ROI 会导致显著差异。
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Magnetic resonance thermometry for hyperthermia in the oropharynx region.

Magnetic resonance thermometry (MRT) can measure in-vivo 3D-temperature changes in real-time and noninvasively. However, for the oropharynx region and the entire head and neck, motion potentially introduces large artifacts. Considering long treatment times of 60-90 min, this study aims to evaluate whether MRT around the oropharynx is clinically feasible for hyperthermia treatments and quantify the effects of breathing and swallowing on MRT performance. A 3D-ME-FGRE sequence was used in a phantom cooling down and around the oropharynx of five volunteers over ∼75 min. The imaging protocol consisted of imaging with acceleration (ARC = 2), number of image averages (NEX = 1,2 and 3). For volunteers, the acquisitions included a breath-hold scan and scans with deliberate swallowing. MRT performance was quantified in neck muscle, spinal cord and masseter muscle, using mean average error (MAE), mean error (ME) and spatial standard deviation (SD). In phantom, an increase in NEX leads to a significant decrease in SD, but MAE and ME were unchanged. No significant difference was found in volunteers between the different scans. There was a significant difference between the regions evaluated: neck muscle had the best MAE (=1.96 °C) and SD (=0.82 °C), followed by spinal cord (MAE = 3.17 °C, SD = 0.92 °C) and masseter muscle (MAE = 4.53 °C, SD = 1.16 °C). Concerning the ME, spinal cord did best, then neck muscle and masseter muscle, with values of -0.64 °C, 1.15 °C and -3.05 °C respectively. Breathing, swallowing, and different ways of imaging (acceleration and NEX) do not significantly influence the MRT performance in the oropharynx region. The ROI selected however, leads to significant differences.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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