探索炎性细胞因子与椎间盘退变之间的因果关系:孟德尔随机试验

IF 3.4 3区 医学 Q1 ORTHOPEDICS JOR Spine Pub Date : 2024-07-10 DOI:10.1002/jsp2.1349
Tao Xu, Guangzi Chen, Jian Li, Yingchi Zhang
{"title":"探索炎性细胞因子与椎间盘退变之间的因果关系:孟德尔随机试验","authors":"Tao Xu,&nbsp;Guangzi Chen,&nbsp;Jian Li,&nbsp;Yingchi Zhang","doi":"10.1002/jsp2.1349","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Inflammatory cytokines have been reported to be related to intervertebral disc degeneration (IVDD) in several previous studies. However, it remains unclear about the causal relationship between inflammatory cytokines and IVDD. This study employs Mendelian randomization (MR) to analyze the causal link between inflammatory cytokines and the risk of IVDD.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>We used genetic variants associated with inflammatory cytokines from a meta-analysis of genome-wide association study (GWAS) in 8293 Finns as instrumental variables and IVDD data were sourced from the FinnGen consortium. The main analytical approach utilized Inverse-Variance Weighting (IVW) with random effects to assess the causal relationship. Additionally, complementary methods such as MR-Egger, weighted median, simple mode, weighted mode, and MR pleiotropy residual sum and outlier were employed to enhance the robustness of the final results.</p>\n </section>\n \n <section>\n \n <h3> Result</h3>\n \n <p>We found interferon-gamma (IFN-γ, <i>p</i> = 2.14 × 10–6, OR = 0.870, 95% CI = 0.821–0.921), interleukin-1 beta (IL-1b, <i>p</i> = 0.012, OR = 0.951, 95% CI = 0.914–0.989), interleukin-4 (IL-4, <i>p</i> = 0.034, OR = 0.946, 95% CI = 0.899–0.996), interleukin-18 (IL-18, <i>p</i> = 0.028, OR = 0.964, 95% CI = 0.934–0.996), granulocyte colony-stimulating factor (GCSF, <i>p</i> = 0.010, OR = 0.919, 95% CI = 0.861–0.980), and Stromal cell-derived factor 1a (SDF1a, <i>p</i> = 0.014, OR = 1.072, 95% CI = 1.014–1.134) were causally associated with risk of IVDD.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Our MR analyses found a potential causal relationship between six inflammation cytokines (IFN-γ, IL-1b, IL-4, IL-18, SDF1a, and GCSF) and altered IVDD risk.</p>\n </section>\n </div>","PeriodicalId":14876,"journal":{"name":"JOR Spine","volume":"7 3","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237178/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exploring causal correlations between inflammatory cytokines and intervertebral disc degeneration: A Mendelian randomization\",\"authors\":\"Tao Xu,&nbsp;Guangzi Chen,&nbsp;Jian Li,&nbsp;Yingchi Zhang\",\"doi\":\"10.1002/jsp2.1349\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Inflammatory cytokines have been reported to be related to intervertebral disc degeneration (IVDD) in several previous studies. However, it remains unclear about the causal relationship between inflammatory cytokines and IVDD. This study employs Mendelian randomization (MR) to analyze the causal link between inflammatory cytokines and the risk of IVDD.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Method</h3>\\n \\n <p>We used genetic variants associated with inflammatory cytokines from a meta-analysis of genome-wide association study (GWAS) in 8293 Finns as instrumental variables and IVDD data were sourced from the FinnGen consortium. The main analytical approach utilized Inverse-Variance Weighting (IVW) with random effects to assess the causal relationship. Additionally, complementary methods such as MR-Egger, weighted median, simple mode, weighted mode, and MR pleiotropy residual sum and outlier were employed to enhance the robustness of the final results.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Result</h3>\\n \\n <p>We found interferon-gamma (IFN-γ, <i>p</i> = 2.14 × 10–6, OR = 0.870, 95% CI = 0.821–0.921), interleukin-1 beta (IL-1b, <i>p</i> = 0.012, OR = 0.951, 95% CI = 0.914–0.989), interleukin-4 (IL-4, <i>p</i> = 0.034, OR = 0.946, 95% CI = 0.899–0.996), interleukin-18 (IL-18, <i>p</i> = 0.028, OR = 0.964, 95% CI = 0.934–0.996), granulocyte colony-stimulating factor (GCSF, <i>p</i> = 0.010, OR = 0.919, 95% CI = 0.861–0.980), and Stromal cell-derived factor 1a (SDF1a, <i>p</i> = 0.014, OR = 1.072, 95% CI = 1.014–1.134) were causally associated with risk of IVDD.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Our MR analyses found a potential causal relationship between six inflammation cytokines (IFN-γ, IL-1b, IL-4, IL-18, SDF1a, and GCSF) and altered IVDD risk.</p>\\n </section>\\n </div>\",\"PeriodicalId\":14876,\"journal\":{\"name\":\"JOR Spine\",\"volume\":\"7 3\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237178/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOR Spine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jsp2.1349\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOR Spine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jsp2.1349","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
引用次数: 0

摘要

背景:以前的一些研究报告称,炎性细胞因子与椎间盘退变(IVDD)有关。然而,炎性细胞因子与 IVDD 之间的因果关系仍不明确。本研究采用孟德尔随机法(MR)分析炎性细胞因子与 IVDD 风险之间的因果关系:我们使用了对8293名芬兰人进行的全基因组关联研究(GWAS)荟萃分析中与炎性细胞因子相关的基因变异作为工具变量,IVDD数据来自FinnGen联盟。主要分析方法是利用带有随机效应的逆方差加权法(IVW)来评估因果关系。此外,还采用了 MR-Egger、加权中位数、简单模式、加权模式、MR 多变量残差和离群值等补充方法,以增强最终结果的稳健性:我们发现干扰素-γ(IFN-γ,p = 2.14 × 10-6,OR = 0.870,95% CI = 0.821-0.921)、白细胞介素-1 beta(IL-1b,p = 0.012,OR = 0.951,95% CI = 0.914-0.989)、白细胞介素-4(IL-4,p = 0.034,OR = 0.946,95% CI = 0.899-0.996)、白细胞介素-18(IL-18,p = 0.028,OR = 0.964,95% CI = 0.934-0.996)、粒细胞集落刺激因子(GCSF,p = 0.010,OR = 0.919,95% CI = 0.861-0.980)和基质细胞衍生因子 1a(SDF1a,p = 0.014,OR = 1.072,95% CI = 1.014-1.134)与 IVDD 风险存在因果关系:我们的磁共振分析发现,六种炎症细胞因子(IFN-γ、IL-1b、IL-4、IL-18、SDF1a 和 GCSF)与 IVDD 风险改变之间存在潜在的因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Exploring causal correlations between inflammatory cytokines and intervertebral disc degeneration: A Mendelian randomization

Background

Inflammatory cytokines have been reported to be related to intervertebral disc degeneration (IVDD) in several previous studies. However, it remains unclear about the causal relationship between inflammatory cytokines and IVDD. This study employs Mendelian randomization (MR) to analyze the causal link between inflammatory cytokines and the risk of IVDD.

Method

We used genetic variants associated with inflammatory cytokines from a meta-analysis of genome-wide association study (GWAS) in 8293 Finns as instrumental variables and IVDD data were sourced from the FinnGen consortium. The main analytical approach utilized Inverse-Variance Weighting (IVW) with random effects to assess the causal relationship. Additionally, complementary methods such as MR-Egger, weighted median, simple mode, weighted mode, and MR pleiotropy residual sum and outlier were employed to enhance the robustness of the final results.

Result

We found interferon-gamma (IFN-γ, p = 2.14 × 10–6, OR = 0.870, 95% CI = 0.821–0.921), interleukin-1 beta (IL-1b, p = 0.012, OR = 0.951, 95% CI = 0.914–0.989), interleukin-4 (IL-4, p = 0.034, OR = 0.946, 95% CI = 0.899–0.996), interleukin-18 (IL-18, p = 0.028, OR = 0.964, 95% CI = 0.934–0.996), granulocyte colony-stimulating factor (GCSF, p = 0.010, OR = 0.919, 95% CI = 0.861–0.980), and Stromal cell-derived factor 1a (SDF1a, p = 0.014, OR = 1.072, 95% CI = 1.014–1.134) were causally associated with risk of IVDD.

Conclusion

Our MR analyses found a potential causal relationship between six inflammation cytokines (IFN-γ, IL-1b, IL-4, IL-18, SDF1a, and GCSF) and altered IVDD risk.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
JOR Spine
JOR Spine ORTHOPEDICS-
CiteScore
6.40
自引率
18.90%
发文量
42
审稿时长
10 weeks
期刊最新文献
The effects of extracellular matrix-degrading enzymes polymorphisms on intervertebral disc degeneration Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first-in-human, Phase 1b, open-label, single-dose study Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration Melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1