Maria Pereira, Matthew Cardeiro, Lexi Frankel, Bryan Greenfield, Kazuaki Takabe, Omar M Rashid
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Patients were matched, and statistical analyses were implemented. Chi-squared, logistic regression, and odds ratio were used to test for significance and to estimate relative risk.</p><p><strong>Results: </strong>A total of 83,941 patients were identified as utilizing prescribed vitamin C. Subsequent matching by Charlson Comorbidity Index (CCI) score and age resulted in two groups of 50,384 patients. The incidence of pancreatic cancer was 243 (0.48%) in the group with a history of vitamin C intake compared to 442 (0.88%) in the control group. The difference was statistically significant by P < 3.174 × 10<sup>-14</sup> with an odds ratio of 0.548 (95% confidence interval (CI): 0.468 - 0.641). Overall, patients without vitamin C prescription had an increased prevalence of pancreatic cancer throughout all ages and regions of the United States when compared to those with a vitamin C prescription. In addition, healthcare costs were higher in total for the control group when compared to the experimental group.</p><p><strong>Conclusions: </strong>This retrospective cohort study found a statistically significant correlation between vitamin C and subsequent incidence of pancreatic cancer. Further studies are recommended to explore vitamin C's redox and cofactor activity in the context of preventing and possibly treating pancreatic cancer, as well as consider pancreatic cancer lifestyle risk factors such as smoking.</p>","PeriodicalId":46797,"journal":{"name":"World Journal of Oncology","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236377/pdf/","citationCount":"0","resultStr":"{\"title\":\"Increased Vitamin C Intake Is Associated With Decreased Pancreatic Cancer Risk.\",\"authors\":\"Maria Pereira, Matthew Cardeiro, Lexi Frankel, Bryan Greenfield, Kazuaki Takabe, Omar M Rashid\",\"doi\":\"10.14740/wjon1854\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Patients with pancreatic cancer have an unfavorable 5-year survival rate of approximately 3% due to diagnosis occurring at advanced stages. 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The incidence of pancreatic cancer was 243 (0.48%) in the group with a history of vitamin C intake compared to 442 (0.88%) in the control group. The difference was statistically significant by P < 3.174 × 10<sup>-14</sup> with an odds ratio of 0.548 (95% confidence interval (CI): 0.468 - 0.641). Overall, patients without vitamin C prescription had an increased prevalence of pancreatic cancer throughout all ages and regions of the United States when compared to those with a vitamin C prescription. In addition, healthcare costs were higher in total for the control group when compared to the experimental group.</p><p><strong>Conclusions: </strong>This retrospective cohort study found a statistically significant correlation between vitamin C and subsequent incidence of pancreatic cancer. 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引用次数: 0
摘要
背景：胰腺癌患者由于确诊时已是晚期，5 年生存率约为 3%。先前的研究认为维生素 C 对胰腺癌有治疗和预防作用：方法：利用一个符合《健康保险可携性和责任法案》（HIPAA）的国家数据库，对有或无维生素 C 摄入史的患者的胰腺癌风险进行评估。数据库使用了国际疾病分类（ICD）代码，特别是 2010 年 1 月至 2020 年 12 月期间的第 10 版国际疾病分类（ICD-10）和第 9 版国际疾病分类（ICD-9）。对患者进行配对，并进行统计分析。采用卡方、逻辑回归和几率比来检验显著性和估计相对风险：根据夏尔森综合症指数（Charlson Comorbidity Index，CCI）评分和年龄进行匹配后，得出两组共 50,384 名患者。有维生素 C 摄入史的一组胰腺癌发病率为 243 例（0.48%），而对照组为 442 例（0.88%）。差异具有统计学意义（P < 3.174 × 10-14），几率比为 0.548（95% 置信区间（CI）：0.468 - 0.641）。总体而言，与有维生素 C 处方的患者相比，没有维生素 C 处方的患者在美国各年龄段和各地区的胰腺癌发病率都有所上升。此外，与实验组相比，对照组的医疗费用总额更高：这项回顾性队列研究发现，维生素 C 与胰腺癌的后续发病率之间存在统计学意义上的显著相关性。建议进一步研究维生素 C 在预防和治疗胰腺癌方面的氧化还原和辅助因子活性，并考虑胰腺癌的生活方式风险因素，如吸烟。
Increased Vitamin C Intake Is Associated With Decreased Pancreatic Cancer Risk.
Background: Patients with pancreatic cancer have an unfavorable 5-year survival rate of approximately 3% due to diagnosis occurring at advanced stages. Prior research has proposed vitamin C may have a therapeutic and preventative role in pancreatic cancer.
Methods: A Health Insurance Portability and Accountability Act (HIPAA) compliant national database was utilized to assess pancreatic cancer risk in patients with or without a history of vitamin C intake. The International Classification of Diseases (ICD) codes were used, specifically the International Classification of Diseases, 10th Edition (ICD-10) and International Classification of Diseases, Nineth Edition (ICD-9), between January 2010 and December 2020. Patients were matched, and statistical analyses were implemented. Chi-squared, logistic regression, and odds ratio were used to test for significance and to estimate relative risk.
Results: A total of 83,941 patients were identified as utilizing prescribed vitamin C. Subsequent matching by Charlson Comorbidity Index (CCI) score and age resulted in two groups of 50,384 patients. The incidence of pancreatic cancer was 243 (0.48%) in the group with a history of vitamin C intake compared to 442 (0.88%) in the control group. The difference was statistically significant by P < 3.174 × 10-14 with an odds ratio of 0.548 (95% confidence interval (CI): 0.468 - 0.641). Overall, patients without vitamin C prescription had an increased prevalence of pancreatic cancer throughout all ages and regions of the United States when compared to those with a vitamin C prescription. In addition, healthcare costs were higher in total for the control group when compared to the experimental group.
Conclusions: This retrospective cohort study found a statistically significant correlation between vitamin C and subsequent incidence of pancreatic cancer. Further studies are recommended to explore vitamin C's redox and cofactor activity in the context of preventing and possibly treating pancreatic cancer, as well as consider pancreatic cancer lifestyle risk factors such as smoking.
期刊介绍：
World Journal of Oncology, bimonthly, publishes original contributions describing basic research and clinical investigation of cancer, on the cellular, molecular, prevention, diagnosis, therapy and prognosis aspects. The submissions can be basic research or clinical investigation oriented. This journal welcomes those submissions focused on the clinical trials of new treatment modalities for cancer, and those submissions focused on molecular or cellular research of the oncology pathogenesis. Case reports submitted for consideration of publication should explore either a novel genomic event/description or a new safety signal from an oncolytic agent. The areas of interested manuscripts are these disciplines: tumor immunology and immunotherapy; cancer molecular pharmacology and chemotherapy; drug sensitivity and resistance; cancer epidemiology; clinical trials; cancer pathology; radiobiology and radiation oncology; solid tumor oncology; hematological malignancies; surgical oncology; pediatric oncology; molecular oncology and cancer genes; gene therapy; cancer endocrinology; cancer metastasis; prevention and diagnosis of cancer; other cancer related subjects. The types of manuscripts accepted are original article, review, editorial, short communication, case report, letter to the editor, book review.
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