病例报告:移植后淋巴增生性疾病是血管化复合异体移植的严重并发症。

Frontiers in transplantation Pub Date : 2024-03-14 eCollection Date: 2024-01-01 DOI:10.3389/frtra.2024.1339898
Alessandra Zaccardelli, Fabienne M Lucas, Ann S LaCasce, Anil K Chandraker, Jamil R Azzi, Simon G Talbot
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引用次数: 0

摘要

血管化复合异体移植(VCA)是移植手术中的一个新兴领域。尽管总体效果良好,但血管化复合异体移植术仍有可能出现与手术和后续免疫抑制相关的多种并发症。移植后淋巴组织增生性疾病(PTLD)是实体器官移植和造血干细胞移植后发生的一组异质性淋巴组织增生性疾病。本文介绍了一名双上肢移植后PTLD患者的情况,并回顾了所有已知的VCA后PTLD病例,重点介绍了这一人群的独特流行病学、表现和治疗方法。
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Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation.

Vascularized composite allotransplantation (VCA) is an emerging field in transplant surgery. Despite overall positive outcomes, VCA confers risk for multiple complications related to the procedure and subsequent immunosuppression. Post-transplant lymphoproliferative disorder (PTLD) is a heterogeneous group of lymphoproliferative disorders occurring after solid organ and hematopoietic stem cell transplant. A patient with PTLD after bilateral upper extremity transplantation is presented as well as a review of all known cases of PTLD after VCA, with a focus on the unique epidemiology, presentation, and treatment in this population.

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