Yohei Nishida , Yusuke Hashimoto , Kumi Orita , Kazuya Nishino , Takuya Kinoshita , Ken Iida , Hiroaki Nakamura
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Cartilage degeneration of early OA were defined as International Cartilage Repair Society (ICRS) grade 1 to 4 in more than 2 compartments or ICRS grade 2 to 4 in 1 compartment. The patients were divided into two groups: those who had cartilage degeneration of early OA at second-look arthroscopy (cartilage degeneration progression group) and those who did not (non-progression group), and the serum COMP values between the two groups were compared.</p></div><div><h3>Results</h3><p>Thirty-one patients were included. There were 8 cases (25.8 %) in progression group and 23 cases (74.2 %) in non-progression group. There were significant differences between the two groups regarding age and change in serum COMP level. 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引用次数: 0
摘要
背景/目的软骨低聚基质蛋白（COMP）可作为骨关节炎（OA）的诊断指标。我们之前的研究表明，血清中的 COMP 水平可用于检测前交叉韧带（ACL）缺损的非 OA 患者的早期软骨变化。然而，目前还没有关于检测早期 OA 软骨退化进展的研究。本研究旨在探讨血清COMP能否检测非OA患者前交叉韧带重建后软骨退变的进展。早期OA软骨退变的定义为国际软骨修复学会（ICRS）1至4级，2个以上分区或ICRS 2至4级，1个分区。将患者分为两组：二维关节镜检查时发现早期 OA 软骨变性的患者（软骨变性进展组）和未发现早期 OA 软骨变性的患者（未进展组），并比较两组患者的血清 COMP 值。结果 31 例患者中，进展组 8 例（25.8%），非进展组 23 例（74.2%）。两组患者在年龄和血清 COMP 水平变化方面存在明显差异。结论 在本研究中，前交叉韧带重建后，软骨退行性变进展组血清COMP水平的增幅明显高于非进展组。纵向血清COMP测量可检测软骨退变的进展。
Longitudinal measurement of serum cartilage oligomeric matrix protein can detect the progression of cartilage degeneration in anterior cruciate ligament reconstruction patients
Background/objective
Cartilage oligomeric matrix protein (COMP) has utility as a diagnostic marker for osteoarthritis (OA). Our previous study revealed that the serum COMP level can be used to detect early cartilage change in non-OA patients with anterior cruciate ligament (ACL)-deficiency. However, there are still no studies on detecting the progression of cartilage degeneration in early OA. The aim of present study was to investigate whether serum COMP can detect the progression of cartilage degeneration after ACL reconstruction in non-OA patients.
Methods
Patients without cartilage degeneration of early OA at ACL reconstruction and whose serum COMP levels could be measured were included in the study. Cartilage degeneration of early OA were defined as International Cartilage Repair Society (ICRS) grade 1 to 4 in more than 2 compartments or ICRS grade 2 to 4 in 1 compartment. The patients were divided into two groups: those who had cartilage degeneration of early OA at second-look arthroscopy (cartilage degeneration progression group) and those who did not (non-progression group), and the serum COMP values between the two groups were compared.
Results
Thirty-one patients were included. There were 8 cases (25.8 %) in progression group and 23 cases (74.2 %) in non-progression group. There were significant differences between the two groups regarding age and change in serum COMP level. In terms of the rate of change in COMP, an increase of more than 1.24-fold was the cut-off value for detecting the progression of cartilage degeneration.
Conclusions
In this study, the increase in serum COMP levels was significantly greater in progressed cartilage degeneration group than non-progression group after ACL reconstruction. Longitudinal serum COMP measurement could detect the progression of cartilage degeneration.
期刊介绍：
The Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology (AP-SMART) is the official peer-reviewed, open access journal of the Asia-Pacific Knee, Arthroscopy and Sports Medicine Society (APKASS) and the Japanese Orthopaedic Society of Knee, Arthroscopy and Sports Medicine (JOSKAS). It is published quarterly, in January, April, July and October, by Elsevier. The mission of AP-SMART is to inspire clinicians, practitioners, scientists and engineers to work towards a common goal to improve quality of life in the international community. The Journal publishes original research, reviews, editorials, perspectives, and letters to the Editor. Multidisciplinary research with collaboration amongst clinicians and scientists from different disciplines will be the trend in the coming decades. AP-SMART provides a platform for the exchange of new clinical and scientific information in the most precise and expeditious way to achieve timely dissemination of information and cross-fertilization of ideas.
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