替代启动子激活致癌程序

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2024-07-12 DOI:10.1038/s41585-024-00919-2
Louise Lloyd
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引用次数: 0

摘要

随着前列腺肿瘤从良性发展为转移性阉割抗性疾病,癌基因转录因子对替代启动子的使用也在增加。对274份良性前列腺组织、局部前列腺肿瘤和转移性耐阉割前列腺癌(mCRPC)活检样本进行的深度RNA测序分析表明,在局部前列腺癌或mCRPC中上调的基因以及已知的癌基因在肿瘤中从单个替代启动子切换到多个启动子的可能性增加。对于下调的基因,则观察到相反的效果。替代启动子使用的增加与前列腺癌进展相关基因的上调有关。
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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