葎草提取物对骨髓祖细胞和内皮细胞的体外效应和机制

IF 3.8 3区 医学 Q2 CELL BIOLOGY Molecular and Cellular Endocrinology Pub Date : 2024-07-10 DOI:10.1016/j.mce.2024.112328
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引用次数: 0

摘要

骨质疏松症是最常见的代谢性骨病,与骨折的高发生率有关。血管生成和充足的血流量在骨骼修复和维持过程中非常重要。雌激素在骨形成、防止骨吸收和维护血管方面发挥着关键作用。激素替代疗法(HRT)对预防骨折大有裨益,但也与癌症和中风等严重副作用有关。植物雌激素是一种有吸引力的替代激素替代疗法,因为它们的化学结构与雌二醇相似,但可以作为选择性调节剂:在乳房和子宫内膜中作为雌激素受体的拮抗剂,在血管内皮和骨骼中作为激动剂。啤酒花中含有多种植物雌激素,这些雌激素已被证实通过阻断或模拟的方式具有雌激素活性。在这项研究中,我们必须评估啤酒花提取物对骨髓祖细胞(BMPCs)成骨和成脂能力以及 EA.hy926 内皮细胞血管生成潜能的体外效应和作用机制。我们的研究表明,啤酒花提取物能提高骨髓祖细胞(BMPCs)的增殖能力,促进其成骨细胞分化,同时降低其促破骨细胞生成的能力;而这些作用是由 MAPK 通路介导的。此外,啤酒花提取物还能防止 BMPCs 的成脂分化,并促进内皮细胞的活性,其机制也部分由 MAPK 介导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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In vitro effects and mechanisms of Humulus lupulus extract on bone marrow progenitor cells and endothelial cells

Osteoporosis is the most common metabolic bone disorder and is associated with a high incidence of fractures. Angiogenesis and adequate blood flow are important during bone repair and maintenance. Estrogens play a key role in bone formation, in the prevention of bone resorption and vasculature maintenance. Hormone replacement therapy (HRT) has been used with great benefits for bone fracture prevention but has been linked to the development of serious important side effects, including cancer and stroke. Phytoestrogens are an attractive alternative to HRT because their chemical structure is similar to estradiol but, they could behave as selective modulators: acting as antagonists of estrogen receptors in the breast and endometrium and as agonists in the vascular endothelium and bone. Hops contain a wide variety of phytoestrogens that have individually been shown to possess estrogenic activity by either blocking or mimicking. In this study we have to evaluate the in vitro effects and mechanisms of action of hops extracts on the osteogenic and adipogenic capacity of bone marrow progenitor cells (BMPCs), and the angiogenic potential of EA.hy926 endothelial cells. We show that hops extracts increase the proliferative capacity of BMPCs and promote their osteogenic differentiation while decreasing their pro-osteoclastogenic capacity; and that these effects are mediated by the MAPK pathway. Additionally, hops extracts prevent the adipogenic differentiation of BMPCs and promote endothelial cell activity, by mechanisms also partially mediated by MAPK.

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来源期刊
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology 医学-内分泌学与代谢
CiteScore
9.00
自引率
2.40%
发文量
174
审稿时长
42 days
期刊介绍: Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.
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