近亲结婚对 iPSC 库设计的影响。

IF 5.9 2区医学 Q1 CELL & TISSUE ENGINEERING Stem Cell Reports Pub Date : 2024-08-13 Epub Date: 2024-07-11 DOI:10.1016/j.stemcr.2024.06.004

Imen F Alkuraya, Edward B De Vol

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引用次数: 0

摘要

近亲结婚对鉴定通用诱导多能干细胞（iPSC）供体（即主要人类白细胞抗原（HLA）基因座的同源基因）的影响尚不清楚。在近亲繁殖人群中，使用基于近亲繁殖系数的方法（1qF）计算发现样本量。与标准方法相比，结果小了几个数量级。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The impact of consanguinity on the design of iPSC banks.

The effect of consanguinity on identifying universal induced pluripotent stem cell (iPSC) donors, i.e., homozygous for the major human leukocyte antigen (HLA) loci, is unknown. The discovery sample size was calculated in a consanguineous population using a method (1qF) based on the inbreeding coefficient. The result was orders of magnitude smaller compared to the standard method.

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来源期刊

Stem Cell Reports CELL & TISSUE ENGINEERING-CELL BIOLOGY

CiteScore

10.50

自引率

1.70%

发文量

200

审稿时长

28 weeks

期刊介绍： Stem Cell Reports publishes high-quality, peer-reviewed research presenting conceptual or practical advances across the breadth of stem cell research and its applications to medicine. Our particular focus on shorter, single-point articles, timely publication, strong editorial decision-making and scientific input by leaders in the field and a "scoop protection" mechanism are reasons to submit your best papers.