杜兴氏肌肉萎缩症矫形治疗的当前概念。

Matthew Weintraub, Arjun Gupta, Ahmed Khokhar, Michael Vives, Neil Kaushal
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引用次数: 0

摘要

杜兴氏肌肉营养不良症(DMD)是一种以进行性肌肉变性为特征的遗传性疾病,给矫形外科带来了显著的挑战,尤其是脊柱侧弯,它会影响患者的坐姿平衡,并使心脏和呼吸功能复杂化,从而降低患者的生活质量。目前的骨科治疗策略强调使用皮质类固醇进行早期干预,以延缓疾病进展,并使用脊柱融合手术治疗严重的脊柱侧弯,目的是增强坐姿平衡,减轻不适,并可能延长患者的寿命。尽管取得了进步,但要实现最佳管理,还需要不断进行研究,以完善治疗方法,确保改善 DMD 患者的预后。本文综述了手术和非手术干预的最新研究成果,强调了针对 DMD 患者的动态需求采取多学科方法的重要性。
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Current Concepts in the Orthopaedic Management of Duchenne Muscular Dystrophy.

Duchenne muscular dystrophy (DMD), a genetic condition marked by progressive muscle degeneration, presents notable orthopaedic challenges, especially scoliosis, which deteriorates patients' quality of life by affecting sitting balance and complicating cardiac and respiratory functions. Current orthopaedic management strategies emphasize early intervention with corticosteroids to delay disease progression and the use of surgical spinal fusion to address severe scoliosis, aiming to enhance sitting balance, alleviate discomfort, and potentially extend patient lifespan. Despite advancements, optimal management requires ongoing research to refine therapeutic approaches, ensuring improved outcomes for patients with DMD. This review synthesizes recent findings on surgical and nonsurgical interventions, underscoring the importance of a multidisciplinary approach tailored to the dynamic needs of patients with DMD.

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来源期刊
CiteScore
2.60
自引率
6.70%
发文量
282
审稿时长
8 weeks
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