免疫介导的转移支持:对骨侵袭的影响

IF 20.1 1区 医学 Q1 ONCOLOGY Cancer Communications Pub Date : 2024-07-14 DOI:10.1002/cac2.12584
Zengfeng Xin, Luying Qin, Yang Tang, Siyu Guo, Fangfang Li, Yuan Fang, Gege Li, Yihan Yao, Binbin Zheng, Bicheng Zhang, Dang Wu, Jie Xiao, Chao Ni, Qichun Wei, Ting Zhang
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引用次数: 0

摘要

在各种晚期癌症(包括肺癌、乳腺癌、前列腺癌、结直肠癌和黑色素瘤)中,骨是受转移影响的常见器官。一旦确诊为骨转移,患者的生活质量和总体生存期都会因各种病症和治疗难度的增加而大大降低。许多研究表明,骨转移与骨微环境,尤其是骨免疫微环境密切相关。然而,骨微环境中各种免疫细胞对骨转移的影响仍不清楚。在此,我们描述了骨转移过程中各种免疫细胞的变化,并探讨了其相关机制。此外,还包括成骨细胞、脂肪细胞和其他与骨转移密切相关的非免疫细胞。本综述还总结了现有的治疗方法和潜在的治疗靶点,并为今后的癌症骨转移研究提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Immune mediated support of metastasis: Implication for bone invasion

Bone is a common organ affected by metastasis in various advanced cancers, including lung, breast, prostate, colorectal, and melanoma. Once a patient is diagnosed with bone metastasis, the patient's quality of life and overall survival are significantly reduced owing to a wide range of morbidities and the increasing difficulty of treatment. Many studies have shown that bone metastasis is closely related to bone microenvironment, especially bone immune microenvironment. However, the effects of various immune cells in the bone microenvironment on bone metastasis remain unclear. Here, we described the changes in various immune cells during bone metastasis and discussed their related mechanisms. Osteoblasts, adipocytes, and other non-immune cells closely related to bone metastasis were also included. This review also summarized the existing treatment methods and potential therapeutic targets, and provided insights for future studies of cancer bone metastasis.

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来源期刊
Cancer Communications
Cancer Communications Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
25.50
自引率
4.30%
发文量
153
审稿时长
4 weeks
期刊介绍: Cancer Communications is an open access, peer-reviewed online journal that encompasses basic, clinical, and translational cancer research. The journal welcomes submissions concerning clinical trials, epidemiology, molecular and cellular biology, and genetics.
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