基于天然化合物的癌症治疗纳米药物:未来的方向和挑战。

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Drug Delivery and Translational Research Pub Date : 2024-10-01 Epub Date: 2024-07-13 DOI:10.1007/s13346-024-01649-z
Tatiana Andreani, Ruoyu Cheng, Khalil Elbadri, Claudio Ferro, Thacilla Menezes, Mayara R Dos Santos, Carlos M Pereira, Hélder A Santos
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引用次数: 0

摘要

与传统的治疗方法相比,使用不同类型的新药和微创疗法来改善癌症治疗效果的工作已经取得了广泛的成果。传统的治疗方法普遍存在许多缺点,如耐药性、非选择性和高成本,从而限制了其临床反应。过去几十年来,应用天然化合物预防和治疗不同的癌细胞已引起医药界和科学界的极大关注。尽管纳米技术在癌症治疗中的应用仍处于初级阶段,但纳米治疗剂的应用已证明可减少与天然化合物的使用有关的各种限制,如物理/化学不稳定性、水溶性差和生物利用度低等。尽管纳米技术有望提高天然化合物的生物利用度,但针对其应用所开展的临床试验仍然有限,临床前和临床试验面临各种挑战,如工业化生产、纳米治疗剂长期稳定性的保证、生理障碍以及安全和监管问题。本综述重点介绍了植物、细菌、真菌和海洋生物分泌的天然化合物纳米载体的最新进展,以及它们在抗癌治疗中对细胞信号通路的作用。此外,还讨论了载入纳米载体的天然化合物在临床应用方面的现状和主要挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges.

Several efforts have been extensively accomplished for the amelioration of the cancer treatments using different types of new drugs and less invasives therapies in comparison with the traditional therapeutic modalities, which are widely associated with numerous drawbacks, such as drug resistance, non-selectivity and high costs, restraining their clinical response. The application of natural compounds for the prevention and treatment of different cancer cells has attracted significant attention from the pharmaceuticals and scientific communities over the past decades. Although the use of nanotechnology in cancer therapy is still in the preliminary stages, the application of nanotherapeutics has demonstrated to decrease the various limitations related to the use of natural compounds, such as physical/chemical instability, poor aqueous solubility, and low bioavailability. Despite the nanotechnology has emerged as a promise to improve the bioavailability of the natural compounds, there are still limited clinical trials performed for their application with various challenges required for the pre-clinical and clinical trials, such as production at an industrial level, assurance of nanotherapeutics long-term stability, physiological barriers and safety and regulatory issues. This review highlights the most recent advances in the nanocarriers for natural compounds secreted from plants, bacteria, fungi, and marine organisms, as well as their role on cell signaling pathways for anticancer treatments. Additionally, the clinical status and the main challenges regarding the natural compounds loaded in nanocarriers for clinical applications were also discussed.

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来源期刊
Drug Delivery and Translational Research
Drug Delivery and Translational Research MEDICINE, RESEARCH & EXPERIMENTALPHARMACOL-PHARMACOLOGY & PHARMACY
CiteScore
11.70
自引率
1.90%
发文量
160
期刊介绍: The journal provides a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. Rationally developed, effective delivery systems can potentially affect clinical outcome in different disease conditions. Research focused on the following areas of translational drug delivery research will be considered for publication in the journal. Designing and developing novel drug delivery systems, with a focus on their application to disease conditions; Preclinical and clinical data related to drug delivery systems; Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes Short-term and long-term biocompatibility of drug delivery systems, host response; Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; Image-guided drug therapy, Nanomedicine; Devices for drug delivery and drug/device combination products. In addition to original full-length papers, communications, and reviews, the journal includes editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of the Controlled Release Society.
期刊最新文献
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