帕金森病患者服用和未服用多巴胺能药物时的关节间协调:一项病例对照研究。

IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of NeuroEngineering and Rehabilitation Pub Date : 2024-07-13 DOI:10.1186/s12984-024-01416-8
Karolina Saegner, Robbin Romijnders, Clint Hansen, Jana Holder, Elke Warmerdam, Walter Maetzler
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引用次数: 0

摘要

背景:人们对关节如何准确运动和相互作用,以及这如何反映出与帕金森病相关的步态异常和对多巴胺能治疗的反应知之甚少。对这些运动学的详细了解可为临床管理和治疗决策提供依据。本研究的目的是调查不同步速和用药/停药条件对关节间协调性的影响,以及特征明确的帕金森病患者在整个步态周期中的运动学差异。方法:29 名对照组和 29 名帕金森病患者在用药期间(其中 8 人也在停药期间)以慢速、优先步速和快步走直线行走。步态数据通过光学运动捕捉系统收集。使用统计参数映射(SPM)和循环图(角度-角度图)对髋关节和膝关节的运动学以及髋关节-膝关节的协调运动学进行评估。组内比较采用重复测量方差分析,组间比较采用 t 检验:结果:帕金森病步态与对照组的主要区别在于膝关节活动范围(ROM)较小。帕金森病患者对步速的适应主要通过增加髋关节活动度来实现。帕金森氏症患者步态的规律性较差,但仅在首选速度时才会出现这种情况。在帕金森氏症组中,不同速度循环图的比率较小。SPM 分析显示,肢体障碍患者在摆动阶段的髋关节和膝关节角度较小,而且肢体障碍患者达到髋关节屈曲峰值的时间晚于对照组。停药后,只有少数参数出现恶化:我们的研究结果表明,粒度运动学分析(包括大于 1 个关节)具有监测帕金森病疾病和治疗的潜力。我们的方法可扩展到更多的活动受限疾病和其他关节组合:该研究已在德国临床试验注册中心注册(DRKS00022998,注册日期为2020年9月4日)。
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Inter-joint coordination with and without dopaminergic medication in Parkinson's disease: a case-control study.

Background: How the joints exactly move and interact and how this reflects PD-related gait abnormalities and the response to dopaminergic treatment is poorly understood. A detailed understanding of these kinematics can inform clinical management and treatment decisions. The aim of the study was to investigate the influence of different gait speeds and medication on/off conditions on inter-joint coordination, as well as kinematic differences throughout the whole gait cycle in well characterized pwPD.

Methods: 29 controls and 29 PD patients during medication on, 8 of them also during medication off walked a straight walking path in slow, preferred and fast walking speeds. Gait data was collected using optical motion capture system. Kinematics of the hip and knee and coordinated hip-knee kinematics were evaluated using Statistical Parametric Mapping (SPM) and cyclograms (angle-angle plots). Values derived from cyclograms were compared using repeated-measures ANOVA for within group, and ttest for between group comparisons.

Results: PD gait differed from controls mainly by lower knee range of motion (ROM). Adaptation to gait speed in PD was mainly achieved by increasing hip ROM. Regularity of gait was worse in PD but only during preferred speed. The ratios of different speed cyclograms were smaller in the PD groups. SPM analyses revealed that PD participants had smaller hip and knee angles during the swing phase, and PD participants reached peak hip flexion later than controls. Withdrawal of medication showed an exacerbation of only a few parameters.

Conclusions: Our findings demonstrate the potential of granular kinematic analyses, including > 1 joint, for disease and treatment monitoring in PD. Our approach can be extended to further mobility-limiting conditions and other joint combinations.

Trial registration: The study is registered in the German Clinical Trials Register (DRKS00022998, registered on 04 Sep 2020).

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来源期刊
Journal of NeuroEngineering and Rehabilitation
Journal of NeuroEngineering and Rehabilitation 工程技术-工程:生物医学
CiteScore
9.60
自引率
3.90%
发文量
122
审稿时长
24 months
期刊介绍: Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.
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