挖掘杜匹单抗治疗嗜酸性粒细胞慢性阻塞性肺病的潜力。

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Med Pub Date : 2024-07-12 DOI:10.1016/j.medj.2024.05.011

Maria Gabriella Matera, Mario Cazzola

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引用次数: 0

摘要

慢性阻塞性肺病（COPD）常伴有1型（T1）炎症，但40%的患者伴有T2型炎症，这会恶化预后。针对白细胞介素（IL）-4和IL-13的Dupilumab在3期试验中显示出良好的前景。新的 NOTUS 试验1 显示，该疗法在减少病情恶化和改善肺功能方面具有疗效。然而，该试验的主要受试者为白人，这限制了试验的普遍性。未来的研究应包括不同的人群，并评估不同疗法与杜必鲁单抗的结合，以改善疗效。

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Exploiting the potential of dupilumab in the treatment of eosinophilic COPD.

Chronic obstructive pulmonary disease (COPD) often involves type 1 (T1) inflammation, but 40% of patients have T2 inflammation, which worsens outcomes. Dupilumab, targeting interleukin (IL)-4 and IL-13, shows promise in phase 3 trials. The new NOTUS trial¹ showed effectiveness in reducing exacerbations and improving lung function. However, its predominantly white population limits generalizability. Future research should include diverse populations and assess different therapies combined with dupilumab to improve outcomes.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.