{"title":"基因-环境相互作用和基因-基因相互作用对两种生物年龄测量的影响：来自台湾生物库参与者的证据（Adv. Biology 7/2024）","authors":"Wan-Yu Lin","doi":"10.1002/adbi.202470071","DOIUrl":null,"url":null,"abstract":"<p><b>Gene-Environment Interactions</b></p><p>Gene-environment interactions on PhenoAgeAccel (age-adjusted PhenoAge) were searched through variance quantitative trait loci (vQTLs) analyses of 111,996 Taiwan Biobank participants. A total of 4 nearly independent vQTLs were identified with <i>p</i> < 5E-8. Further studies showed that smoking exacerbated the vQTLs' aging effects, while higher educational attainment attenuated these effects. More details can be found in article number 2400149 by Wan-Yu Lin.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":"8 7","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202470071","citationCount":"0","resultStr":"{\"title\":\"Gene-Environment Interactions and Gene–Gene Interactions on Two Biological Age Measures: Evidence from Taiwan Biobank Participants (Adv. Biology 7/2024)\",\"authors\":\"Wan-Yu Lin\",\"doi\":\"10.1002/adbi.202470071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Gene-Environment Interactions</b></p><p>Gene-environment interactions on PhenoAgeAccel (age-adjusted PhenoAge) were searched through variance quantitative trait loci (vQTLs) analyses of 111,996 Taiwan Biobank participants. A total of 4 nearly independent vQTLs were identified with <i>p</i> < 5E-8. Further studies showed that smoking exacerbated the vQTLs' aging effects, while higher educational attainment attenuated these effects. More details can be found in article number 2400149 by Wan-Yu Lin.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":7234,\"journal\":{\"name\":\"Advanced biology\",\"volume\":\"8 7\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202470071\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adbi.202470071\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced biology","FirstCategoryId":"99","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adbi.202470071","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Gene-Environment Interactions and Gene–Gene Interactions on Two Biological Age Measures: Evidence from Taiwan Biobank Participants (Adv. Biology 7/2024)
Gene-Environment Interactions
Gene-environment interactions on PhenoAgeAccel (age-adjusted PhenoAge) were searched through variance quantitative trait loci (vQTLs) analyses of 111,996 Taiwan Biobank participants. A total of 4 nearly independent vQTLs were identified with p < 5E-8. Further studies showed that smoking exacerbated the vQTLs' aging effects, while higher educational attainment attenuated these effects. More details can be found in article number 2400149 by Wan-Yu Lin.
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