{"title":"多取代吡唑的合成及其生物应用","authors":"Appalanaidu Satipidakala , Ramakrishna Rao Bhonsle , Ramana Tamminana","doi":"10.1080/00397911.2024.2377283","DOIUrl":null,"url":null,"abstract":"<div><p>Novel library of pyrazole derivatives (<strong>6a–k)</strong> from substituted 4-dioxaborolanyl-1<em>H</em>-pyrazole and halo benzaldehyde through simultaneous Suzuki reaction, nucleophilic addition, and hydrolysis under moderate reaction conditions. The desired compounds <strong>6a–k</strong> have been formed in good to high yield. All the compound structures were characterized by analytical and spectral (<sup>1</sup>H NMR,<sup>13</sup>C NMR and MS) studies. Furthermore, the evaluation of biological activity of synthesized molecules.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of polysubstituted pyrazoles and their biological applications\",\"authors\":\"Appalanaidu Satipidakala , Ramakrishna Rao Bhonsle , Ramana Tamminana\",\"doi\":\"10.1080/00397911.2024.2377283\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Novel library of pyrazole derivatives (<strong>6a–k)</strong> from substituted 4-dioxaborolanyl-1<em>H</em>-pyrazole and halo benzaldehyde through simultaneous Suzuki reaction, nucleophilic addition, and hydrolysis under moderate reaction conditions. The desired compounds <strong>6a–k</strong> have been formed in good to high yield. All the compound structures were characterized by analytical and spectral (<sup>1</sup>H NMR,<sup>13</sup>C NMR and MS) studies. Furthermore, the evaluation of biological activity of synthesized molecules.</p></div>\",\"PeriodicalId\":22119,\"journal\":{\"name\":\"Synthetic Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synthetic Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S0039791124000638\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthetic Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0039791124000638","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Synthesis of polysubstituted pyrazoles and their biological applications
Novel library of pyrazole derivatives (6a–k) from substituted 4-dioxaborolanyl-1H-pyrazole and halo benzaldehyde through simultaneous Suzuki reaction, nucleophilic addition, and hydrolysis under moderate reaction conditions. The desired compounds 6a–k have been formed in good to high yield. All the compound structures were characterized by analytical and spectral (1H NMR,13C NMR and MS) studies. Furthermore, the evaluation of biological activity of synthesized molecules.
期刊介绍：
Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.
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