人主动脉瓣狭窄衍生的细胞外囊泡通过 AT1R/NADPH 氧化酶/SGLT2 促氧化剂途径诱导内皮功能障碍和血栓形成

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS JACC: Basic to Translational Science Pub Date : 2024-07-01 DOI:10.1016/j.jacbts.2024.02.012

Sandy Hmadeh PhD , Antonin Trimaille MD, MSc , Kensuke Matsushita MD, PhD , Benjamin Marchandot MD , Adrien Carmona MD , Fatiha Zobairi BSc , Chisato Sato MD, PhD , Michel Kindo MD, PhD , Tam Minh Hoang MD , Florence Toti PhD , Kazem Zibara PhD , Eva Hamade PhD , Valérie Schini-Kerth PhD , Gilles Kauffenstein PhD , Olivier Morel MD, PhD

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引用次数: 0

摘要

病理组织会释放多种因子，包括活化或凋亡细胞脱落的细胞外囊泡 (EV)。滞留在原生病理瓣膜内的 EVs 可能是瓣膜血栓形成的关键介质。人类主动脉瓣狭窄 EVs 可促进瓣膜内皮细胞的活化，导致内皮功能障碍以及促粘附和促凝血反应。

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Human Aortic Stenotic Valve-Derived Extracellular Vesicles Induce Endothelial Dysfunction and Thrombogenicity Through AT1R/NADPH Oxidases/SGLT2 Pro-Oxidant Pathway

Pathological tissues release a variety of factors, including extracellular vesicles (EVs) shed by activated or apoptotic cells. EVs trapped within the native pathological valves may act as key mediators of valve thrombosis. Human aortic stenosis EVs promote activation of valvular endothelial cells, leading to endothelial dysfunction, and proadhesive and procoagulant responses.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.