灵芝和扁豆蘑菇提取物载入的niosomes具有协同抗癌和抗菌作用

IF 1.6 4区 工程技术 Q3 CHEMISTRY, APPLIED Journal of Surfactants and Detergents Pub Date : 2024-07-11 DOI:10.1002/jsde.12782
Saeed Zalnezhad, Mahboubeh Adeli‐Sardou, Maryam Roostaee, Mahmood Barani, Mohammad Mirzaei, Ghasem Sargazi
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引用次数: 0

摘要

本研究探讨了灵芝和冬菇提取物通过niosomes(由Span 40、Tween 40和胆固醇组成)输送抗癌和抗菌应用的潜在协同效应。气相色谱-质谱分析揭示了提取物中的生物活性化合物,如 d-柠檬烯、抗坏血酸和麦角甾醇,它们具有众所周知的抗癌和抗菌作用。这些niosomes制剂的物理性质有所改善,尺寸范围在96到160纳米之间,多分散指数(PDI)值在0.29-0.54之间,表明niosomes具有可接受的尺寸分布和均匀性。在细胞培养研究中,niosomal 配方对 A549 肺癌细胞有显著的细胞毒性作用,两种提取物的组合使细胞存活率明显降低至 14.86%。此外,G. lucidum 和 L. edodes 提取物的组合纳米制剂对致病细菌(铜绿假单胞菌和金黄色葡萄球菌)和真菌(白色念珠菌)表现出不同的强效抗菌特性,其最低抑菌浓度 (MIC) 值低于其游离态,表明存在潜在的协同效应。研究结果凸显了通过niosomes递送的联合蘑菇提取物具有潜在的协同抗癌和抗菌作用,为开发新型药物递送系统提供了宝贵的见解。
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Synergistic anti‐cancer and antimicrobial effects of Ganoderma lucidum and Lentinus edodes mushroom extracts‐loaded niosomes
This study investigates the potential synergy effect of Ganoderma lucidum and Lentinus edodes mushroom extracts delivered through niosomes (composed of Span 40, Tween 40, and cholesterol) for anti‐cancer and antimicrobial applications. GC–MS analysis revealed bioactive compounds such as d‐limonene, ascorbic acid, and ergosterol in the extracts, known for their anti‐cancer and antimicrobial effects. The niosomal formulations exhibited improved physical properties, with sizes ranging from 96 to 160 nm and polydispersity index (PDI) values in the range of 0.29–0.54, suggesting that the niosomes had an acceptable size distribution and homogeneity. In cell culture studies, the niosomal formulations demonstrated significant cytotoxic effects on A549 lung cancer cells, with the combination of both extracts leading to a notable decrease in cell viability to 14.86%. Additionally, the combination of G. lucidum and L. edodes extracts in niosomal form showed varying and potent antimicrobial properties against pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and fungi (Candida albicans) with lower minimum inhibitory concentration (MIC) values compared to their free form, indicating a potential synergistic effect. The findings highlight the potential synergistic anti‐cancer and antimicrobial effects of the combined mushroom extracts delivered through niosomes, offering valuable insights for developing novel drug delivery systems.
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来源期刊
Journal of Surfactants and Detergents
Journal of Surfactants and Detergents 工程技术-工程:化工
CiteScore
3.80
自引率
6.20%
发文量
68
审稿时长
4 months
期刊介绍: Journal of Surfactants and Detergents, a journal of the American Oil Chemists’ Society (AOCS) publishes scientific contributions in the surfactants and detergents area. This includes the basic and applied science of petrochemical and oleochemical surfactants, the development and performance of surfactants in all applications, as well as the development and manufacture of detergent ingredients and their formulation into finished products.
期刊最新文献
Issue Information Cloning, purification, and functional characterization of recombinant pullulanase from Bacillus cereusATCC 14579 for improved detergent performance Special Issue: Glycolipid biosurfactants: Synthesis, properties, and applications Synthesis and properties of sodium stearyl polyoxypropylene acetates Study on the Pickering emulsions stabilized by SiO2 nanoparticles for enhanced oil recovery
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