组织失饱和度不是骨骼肌反应性充血老化相关损伤的主要决定因素:回顾性分析

IF 2.2 3区 医学 Q3 PHYSIOLOGY American journal of physiology. Regulatory, integrative and comparative physiology Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI:10.1152/ajpregu.00130.2024
Thiago Silveira Alvares, Rogerio Nogueira Soares
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引用次数: 0

摘要

近红外光谱(NIRS)结合血管闭塞测试(NIRS-VOT)是一种反应性充血技术,用于在体内评估骨骼肌微血管反应性。以往使用 NIRS-VOT 进行的研究表明,它能够检测高危心血管疾病(CVD)人群(如老年人)的微血管功能损伤。研究表明,老年人的反应性充血比年轻人慢。重要的是,与年轻人相比,老年人在缺血过程中的失饱和度也较低。基于这些研究结果,有人认为老年人反应性充血较慢的原因是血流闭塞时(缺血刺激减少)的失饱和度较低。这项回顾性分析比较了接受 5 分钟血流闭塞治疗的 36 名年轻人和 47 名组织饱和度匹配的老年人的反应性充血情况。总体而言,我们发现,与年轻人相比,在匹配组织饱和度和血流闭塞时间的情况下,老年人的反应性充血功能受损。这些研究结果提供了证据,证明缺血期间较低的组织失饱和度并不是老年人反应性充血受损的主要决定因素。
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Tissue desaturation is not a major determinant of aging-related impairment in skeletal muscle reactive hyperemia: a retrospective analysis.

Near-infrared spectroscopy combined with vascular occlusion test (NIRS-VOT) is a reactive hyperemia technique for in vivo evaluation of skeletal muscle microvascular reactivity. Previous studies using NIRS-VOT have been shown to be able to detect impairments in microvascular function in high-risk cardiovascular disease populations, such as older individuals. It has been demonstrated that older individuals have slower reactive hyperemia compared with young individuals. Importantly, older individuals also show less desaturation during ischemia compared with young individuals. Based on these findings, it has been suggested that the slower reactive hyperemia observed in older individuals is explained by the lower desaturation during blood flow occlusion (reduced ischemic stimulus). This retrospective analysis compared reactive hyperemia in 36 young and 47 older tissue desaturation-matched individuals that underwent 5-min blood flow occlusion. Overall, we showed that older individuals have impaired reactive hyperemia compared with young when matching for the degree of desaturation and blood flow occlusion time. These findings provide evidence that lower tissue desaturation during ischemia is not a major determinant of impaired reactive hyperemia in older individuals.NEW & NOTEWORTHY Previous findings have suggested that aging-related impairment in skeletal muscle reactive hyperemia is majorly influenced by a lower degree of tissue desaturation during ischemia in older individuals compared with young individuals. In a retrospective analysis including 83 tissue desaturation-matched individuals, we show that the degree of tissue desaturation is not a major determinant of aging-related impairments in reactive hyperemia.

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来源期刊
CiteScore
5.30
自引率
3.60%
发文量
145
审稿时长
2 months
期刊介绍: The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.
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