高雄激素血症对多囊卵巢综合征患者妊娠并发症和妊娠结局的影响:系统综述和荟萃分析。

IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-07-14 DOI:10.1080/10641955.2024.2379389
Xiaohan Guo, Yingsha Yao, Ting Wang, Juanhong Wu, Ruoan Jiang
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引用次数: 0

摘要

背景:多囊卵巢综合征(PCOS多囊卵巢综合征(PCOS)是一种代谢和生殖疾病。目前的研究结果表明,不同的多囊卵巢综合征表型对妊娠和新生儿结局的影响存在相互矛盾的观点:本研究遵循《系统综述和元分析首选报告项目》(PRISMA)的指导原则。我们使用科克伦月经失调与不孕症小组试验登记簿、Web of Science 和 EMBASE 数据库对从开始到 2023 年 12 月的文献进行了全面检索。检索的重点是研究高雄激素和非高雄激素多囊卵巢综合症表型与妊娠和新生儿风险之间的联系。采用固定效应或随机效应模型计算出比值比 (OR) 和 95% 置信区间 (CI):我们的分析纳入了 10 项研究。与非高雄激素多囊卵巢综合征亚型的准妈妈相比,高雄激素多囊卵巢综合征亚型的准妈妈妊娠糖尿病(GDM)和子痫前期(PE)的OR值更高,分别为2.14(95% CI,1.18-3.88,I2 = 0%)和2.04(95% CI,1.02-4.08,I2 = 53%)。尽管如此,高雄激素多囊卵巢综合征表型孕妇与非高雄激素多囊卵巢综合征表型孕妇在早产、活产、流产、剖宫产、妊娠高血压、小胎龄儿、大胎龄新生儿和新生儿重症监护室入院等结果的ORs方面没有发现明显差异:这项荟萃分析强调,高雄激素会增加多囊卵巢综合征人群患 GDM 和 PE 的风险。医疗服务提供者应该意识到这种联系,以改善对患者的管理。
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The impact of hyperandrogenemia on pregnancy complications and outcomes in patients with PCOS: a systematic review and meta-analysis.

Background: Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder. Current research findings present conflicting views on the effects of different PCOS phenotypes on outcomes in pregnancy and for newborns.

Methods: This research study followed the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). A thorough search of literature was carried out using the Cochrane Menstrual Disorders and Subfertility Group trials register, Web of Science, and EMBASE databases from their start to December 2023. The search focused on studies examining the links between hyperandrogenic and non-hyperandrogenic PCOS phenotypes and risks in pregnancy and neonatology. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using either a fixed-effects or random-effects model.

Results: Our analysis incorporated 10 research studies. Expectant mothers with a hyperandrogenic PCOS subtype had increased ORs for gestational diabetes mellitus (GDM) and preeclampsia (PE) compared to those with a non-hyperandrogenic PCOS subtype, with respective values of 2.14 (95% CI, 1.18-3.88, I2 = 0%) and 2.04 (95% CI, 1.02-4.08, I2 = 53%). Nevertheless, no notable differences were detected in ORs for outcomes like preterm birth, live birth, miscarriage, cesarean delivery, pregnancy-induced hypertension, small for gestational age babies, large for gestational age newborns, and neonatal intensive care unit admissions between pregnant women with hyperandrogenic PCOS phenotype and those without.

Conclusions: This meta-analysis highlights that the presence of hyperandrogenism heightens the risks of GDM and PE within the PCOS population. Healthcare providers ought to be aware of this connection for improved patient management.

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来源期刊
Hypertension in Pregnancy
Hypertension in Pregnancy 医学-妇产科学
CiteScore
3.40
自引率
0.00%
发文量
21
审稿时长
6 months
期刊介绍: Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.
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