"强心苷--过去、现在和未来？

IF 3.1 4区医学 Q2 PHARMACOLOGY & PHARMACY Naunyn-Schmiedeberg's archives of pharmacology Pub Date : 2024-12-01 Epub Date: 2024-07-15 DOI:10.1007/s00210-024-03285-3

Julia Fender, Johanna Klöcker, Valérie Boivin-Jahns, Ursula Ravens, Roland Jahns, Kristina Lorenz

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引用次数: 0

摘要

迄今为止，洋地黄苷（又称 "强心苷"）是 Na+/K+-ATP 酶的抑制剂。尽管众所周知，洋地黄苷的治疗范围较窄，而且关于其在这些适应症中存在的理由的讨论也很激烈，但作为用于心力衰竭和心房颤动患者的药物，洋地黄苷却有着悠久的历史。本文将回顾这些药物的历史、基础和临床研究的主要发现以及潜在的监督利弊。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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"Cardiac glycosides"-quo vaditis?-past, present, and future?

Up to date, digitalis glycosides, also known as "cardiac glycosides", are inhibitors of the Na⁺/K⁺-ATPase. They have a long-standing history as drugs used in patients suffering from heart failure and atrial fibrillation despite their well-known narrow therapeutic range and the intensive discussions on their raison d'être for these indications. This article will review the history and key findings in basic and clinical research as well as potentially overseen pros and cons of these drugs.

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来源期刊

Naunyn-Schmiedeberg's archives of pharmacology 医学-药学

CiteScore

6.20

自引率

5.60%

发文量

142

审稿时长

4-8 weeks

期刊介绍： Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.