Marine-Lehnhart综合征中甲状腺乳头状癌的罕见病例--甲状腺热结节活检的指征?

JCEM case reports Pub Date : 2024-07-12 eCollection Date: 2024-07-01 DOI:10.1210/jcemcr/luae116
Jimmy Masjkur, Martin Thurnheer, Ole Christopher Maas, Roland Schuler, Christopher Strey
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引用次数: 0

摘要

巴塞杜氏病(GD)同时伴有自主功能性甲状腺结节(AFTNs)的情况并不常见,这种情况被称为马林-雷恩哈特综合征(MLS)。虽然MLS中的功能亢进结节通常是良性的,但也存在罕见的恶性可能性。一名 41 岁的男性患者被诊断为 MLS 1 型,起初采取保守治疗。然而,由于出现了阻塞性症状,患者在发病 4 年后接受了甲状腺切除术。组织学分析显示,患者有2处颈部淋巴结转移和AFTN内的甲状腺乳头状癌(PTC)。
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A Rare Case of Papillary Thyroid Carcinoma in Marine-Lehnhart Syndrome-Indication for Biopsy of Hot Thyroid Nodules?

An uncommon occurrence in which Graves disease (GD) coincides with autonomous functioning thyroid nodules (AFTNs) is termed Marine-Lehnhart syndrome (MLS). While hyperfunctioning nodules in MLS are commonly benign, there exists a rare potential for malignancy. A 41-year-old male patient was initially managed conservatively upon being diagnosed with MLS type 1. However, the emergence of obstructive symptoms prompted a thyroidectomy 4 years after initial presentation. Histological analysis revealed 2 cervical lymph node metastases and papillary thyroid cancer (PTC) within the AFTN.

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