接种 COVID-19 疫苗后的特发性突发性感音神经性听力损失：系统回顾和荟萃分析。

IF 1.9 3区医学 Q2 OTORHINOLARYNGOLOGY European Archives of Oto-Rhino-Laryngology Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI:10.1007/s00405-024-08839-y

Lee Alper, Yahav Oron, Ophir Handzel, Rani Abu-Eta, Nidal Muhanna, Omer J Ungar

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引用次数: 0

摘要

目的对 COVID-19 疫苗与特发性突发性感音神经性听力损失（ISSNHL）发病率之间的关系进行汇总分析：数据来源："Medline"、"PubMed"、"EMBASE "和 "Google scholar"：使用与 COVID-19 疫苗相关的检索词检查 2020 年 1 月至 2024 年 1 月的数据源。纳入的论文报告了接种疫苗人群的数量以及这些人群中 ISSNHL 的发病率。采用纽卡斯尔-渥太华质量评估量表标准进行质量评估：定量数据综合包括三篇出版物，涉及超过 1.918 亿名患者和至少 2.83 亿剂疫苗。COVID-19疫苗接种者中ISSNHL的汇总报告发病率（95%置信区间）为每10万人1.2588例（0.1385-3.4836）。这一发病率明显低于美国和欧盟报告的发病率，美国和欧盟的发病率分别为每 10 万人中 5-27 例和 60 例（P 结论）：没有证据表明 COVID-19 疫苗与 ISSNHL 的发病率有关。

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Idiopathic sudden sensorineural hearing loss after COVID-19 vaccination: a systematic review and meta-analysis.

Objective: To provide pooled analyses on the association between COVID-19 vaccine and the incidence of idiopathic sudden sensorineural hearing loss (ISSNHL).

Data sources: "Medline" via "PubMed", "EMBASE", and "Google scholar".

Review methods: Data sources were inspected from January 2020 to January 2024 using search terms relevant to vaccines for COVID-19. Included were papers with reported numbers of vaccinated populations and incidence if ISSNHL in those populations. Quality assessment was performed with the Newcastle-Ottawa Quality Assessment Scale Criteria.

Results: Three publications encompassing more than 191.8 million patients and at least 283 million vaccine doses were included in the quantitative data synthesis. The pooled reported incidence (95%confidence interval) of ISSNHL among COVID-19 vaccine recipients was 1.2588 per 100,000 (0.1385-3.4836). This incidence is significantly lower than the incidence of 5-27 and 60 per 100,000/year reported in the United States and in the European Union, respectively (P < 0.0001).

Conclusion: There is no evidence to indicate that the COVID-19 vaccine is associated with the incidence of ISSNHL.

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.