{"title":"氯吡格雷耐药性及其对急性冠状动脉综合征临床疗效的影响","authors":"Heemanshu Lodhi , Keshavamurthy Ganapathy Bhat , Vivek Singh Guleria , Ratheesh Kumar Janardhana Pillai , Ribhu Goel , Nitin Sharma , Anuka Sharma , Varun Sharma","doi":"10.1016/j.ihj.2024.07.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>The genetic polymorphism of CYP2C19 influences clopidogrel metabolism and resistance. Aim was to assess the association between CYP2C19 loss of function variation, clopidogrel resistance based on platelet reactivity units and clinical outcomes.</p></div><div><h3>Methods</h3><p>A total of 668 patients of Acute Coronary Sundrome (ACS) who underwent Percutaneous Coronary Intervention (PCI) were subjected to genetic screening and 143 patients undrewent platelet function test to study the association between drug metabolization and its effects based on platelet reactivity unit values.</p></div><div><h3>Results</h3><p>Clopidogrel resistance with CYP2C 19 loss of function variation was noted in 54.64% of patients. Clinical outcomes, such as target vessel revascularization, target lesion revascularization, in-stent restenosis, and stent thrombosis, were also studied.</p></div><div><h3>Conclusion</h3><p>CYP2C19 loss of function variation is strongly associated with clopidogrel resistance and adverse clinical outcomes.</p></div>","PeriodicalId":13384,"journal":{"name":"Indian heart journal","volume":"76 4","pages":"Pages 268-270"},"PeriodicalIF":1.4000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S001948322400155X/pdfft?md5=2de61b95e95ec8bc0b931d5592adf0a9&pid=1-s2.0-S001948322400155X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Clopidogrel resistance and its effect on clinical outcomes in acute coronary syndrome\",\"authors\":\"Heemanshu Lodhi , Keshavamurthy Ganapathy Bhat , Vivek Singh Guleria , Ratheesh Kumar Janardhana Pillai , Ribhu Goel , Nitin Sharma , Anuka Sharma , Varun Sharma\",\"doi\":\"10.1016/j.ihj.2024.07.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>The genetic polymorphism of CYP2C19 influences clopidogrel metabolism and resistance. Aim was to assess the association between CYP2C19 loss of function variation, clopidogrel resistance based on platelet reactivity units and clinical outcomes.</p></div><div><h3>Methods</h3><p>A total of 668 patients of Acute Coronary Sundrome (ACS) who underwent Percutaneous Coronary Intervention (PCI) were subjected to genetic screening and 143 patients undrewent platelet function test to study the association between drug metabolization and its effects based on platelet reactivity unit values.</p></div><div><h3>Results</h3><p>Clopidogrel resistance with CYP2C 19 loss of function variation was noted in 54.64% of patients. Clinical outcomes, such as target vessel revascularization, target lesion revascularization, in-stent restenosis, and stent thrombosis, were also studied.</p></div><div><h3>Conclusion</h3><p>CYP2C19 loss of function variation is strongly associated with clopidogrel resistance and adverse clinical outcomes.</p></div>\",\"PeriodicalId\":13384,\"journal\":{\"name\":\"Indian heart journal\",\"volume\":\"76 4\",\"pages\":\"Pages 268-270\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S001948322400155X/pdfft?md5=2de61b95e95ec8bc0b931d5592adf0a9&pid=1-s2.0-S001948322400155X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian heart journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S001948322400155X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian heart journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S001948322400155X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Clopidogrel resistance and its effect on clinical outcomes in acute coronary syndrome
Aim
The genetic polymorphism of CYP2C19 influences clopidogrel metabolism and resistance. Aim was to assess the association between CYP2C19 loss of function variation, clopidogrel resistance based on platelet reactivity units and clinical outcomes.
Methods
A total of 668 patients of Acute Coronary Sundrome (ACS) who underwent Percutaneous Coronary Intervention (PCI) were subjected to genetic screening and 143 patients undrewent platelet function test to study the association between drug metabolization and its effects based on platelet reactivity unit values.
Results
Clopidogrel resistance with CYP2C 19 loss of function variation was noted in 54.64% of patients. Clinical outcomes, such as target vessel revascularization, target lesion revascularization, in-stent restenosis, and stent thrombosis, were also studied.
Conclusion
CYP2C19 loss of function variation is strongly associated with clopidogrel resistance and adverse clinical outcomes.
期刊介绍：
Indian Heart Journal (IHJ) is the official peer-reviewed open access journal of Cardiological Society of India and accepts articles for publication from across the globe. The journal aims to promote high quality research and serve as a platform for dissemination of scientific information in cardiology with particular focus on South Asia. The journal aims to publish cutting edge research in the field of clinical as well as non-clinical cardiology - including cardiovascular medicine and surgery. Some of the topics covered are Heart Failure, Coronary Artery Disease, Hypertension, Interventional Cardiology, Cardiac Surgery, Valvular Heart Disease, Pulmonary Hypertension and Infective Endocarditis. IHJ open access invites original research articles, research briefs, perspective, case reports, case vignette, cardiovascular images, cardiovascular graphics, research letters, correspondence, reader forum, and interesting photographs, for publication. IHJ open access also publishes theme-based special issues and abstracts of papers presented at the annual conference of the Cardiological Society of India.
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