Bencaosome [16:0 Lyso PA+XLGB28-sRNA] 通过同时促进小鼠骨生成和抑制破骨细胞生成来改善骨质疏松症。

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY IUBMB Life Pub Date : 2024-07-16 DOI:10.1002/iub.2857
Xinyi Du, Shaoting Guo, Xuemeng Mu, Song Mei, Rui Yang, Hengyan Zhang, Chengyu Jiang, Jia Zhang
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引用次数: 0

摘要

骨质疏松症(Osteoporosis,OP)是一种全身性代谢性骨病,会导致骨强度降低和骨折易感性增加,是全球重大的公共卫生和经济问题。由于抗骨质疏松症药物的严重副作用或长期使用的高昂费用,其临床应用受到了限制。仙灵骨葆方是骨科常用的治疗骨质疏松症的有效中药,但其作用机制尚不清楚。在这项研究中,我们筛选了 40 个从 XLGB 胶囊中提取的小 RNA,发现靶向 TNFSF11 的 XLGB28-sRNA 在体外和体内同时促进成骨和抑制破骨细胞生成,具有显著的抗骨质疏松症作用。口服 bencaosome [16:0 Lyso PA+XLGB28-sRNA] 能有效提高小鼠的骨矿物质密度,减少对骨微结构的破坏。这些结果表明,XLGB28-sRNA 可能是一种促进小鼠成骨和抑制破骨细胞生成的新型寡核苷酸药物。
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Bencaosome [16:0 Lyso PA+XLGB28-sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice

Osteoporosis (OP) is a systemic metabolic bone disease resulting in reduced bone strength and increased susceptibility to fractures, making it a significant public health and economic problem worldwide. The clinical use of anti-osteoporosis agents is limited because of their serious side effects or the high cost of long-term use. The Xianlinggubao (XLGB) formula is an effective traditional Chinese herbal medicine commonly used in orthopedics to treat osteoporosis; however, its mechanism of action remains unclear. In this study, we screened 40 small RNAs derived from XLGB capsules and found that XLGB28-sRNA targeting TNFSF11 exerted a significant anti-osteoporosis effect in vitro and in vivo by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis. Oral administration of bencaosome [16:0 Lyso PA+XLGB28-sRNA] effectively improved bone mineral density and reduced the damage to the bone microstructure in mice. These results suggest that XLGB28-sRNA may be a novel oligonucleotide drug that promotes osteogenesis and inhibits osteoclastogenesis in mice.

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来源期刊
IUBMB Life
IUBMB Life 生物-生化与分子生物学
CiteScore
10.60
自引率
0.00%
发文量
109
审稿时长
4-8 weeks
期刊介绍: IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.
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