2015 年至 2021 年阿片类药物使用障碍和酒精使用障碍的处方药使用趋势:加拿大某省的全民研究。

IF 4.2 3区 医学 Q1 SUBSTANCE ABUSE Journal of Addiction Medicine Pub Date : 2024-07-16 DOI:10.1097/ADM.0000000000001348
Kearley Abbott, Rachel Hyrsak, James M Bolton, Jitender Sareen, Murray W Enns, Geoffrey Konrad, Erin Knight, Sherif Eltonsy, Kaarina Kowalec, Jamison Falk, Silvia Alessi-Severini, Kun Liu, Heather Prior, Christine Leong
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引用次数: 0

摘要

目的研究 2015 年至 2021 年阿片类药物使用障碍(OUD)和酒精使用障碍(AUD)的季度发病率和流行率:方法:利用马尼托巴省卫生政策中心提供的行政报销数据,在加拿大马尼托巴省开展了一项全人口范围的回顾性观察研究,以检查 2015 年 1 月 1 日至 2021 年 12 月 31 日期间每个季度每 10,000 人中阿片类药物使用障碍(美沙酮、丁丙诺啡-纳洛酮、丁丙诺啡)或酒精使用障碍药物(纳曲酮、阿坎酸盐、双硫仑)的发生率和流行率:在 2020 年第一季度,分别有 1179 人和 451 人接受了至少一种治疗 OUD 和 AUD 的处方。从 2015 年 1 月 1 日到 2021 年 12 月 31 日,每 10,000 人中的 OUD 药物流行率从 6.3 增至 14.3,增加了一倍多。同样,从 2015 年 1 月 1 日到 2021 年 12 月 31 日,AUD 药物流行率从每 10,000 人中 0.68 例增加到 6.5 例,几乎增加了 10 倍,这主要归功于纳曲酮。在研究期间,AUD 处方使用的发生率从万分之 0.29 增加到万分之 2.51,增加了 8.6 倍。相比之下,阿片类激动剂治疗的发生率从 2015 年第一季度的万分之 2.1 降至 2016 年第一季度的万分之 0.53,这主要是美沙酮造成的。虽然美沙酮的使用率有所下降,但丁丙诺啡-纳洛酮的使用率在研究期间却增加了近15倍:结论:除丁丙诺啡-纳洛酮发病率增加外,还观察到 AUD 药物流行率和发病率均有所增加。这些研究结果反映出,随着治疗 AUD 和 OUD 的药物覆盖面和可及性的扩大,这些药物的使用率也在增加。
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Trend in Prescription Medication Utilization for Opioid Use Disorder and Alcohol Use Disorder From 2015 to 2021: A Population-wide Study in a Canadian Province.

Objective: To examine the quarterly incidence and prevalence of medications for opioid use disorder (OUD) and alcohol use disorder (AUD) from 2015 to 2021.

Methods: A retrospective population-wide observational study in Manitoba, Canada, was conducted using administrative claims data from the Manitoba Centre for Health Policy to examine the incidence and prevalence of OUD (methadone, buprenorphine-naloxone, buprenorphine) or AUD medications (naltrexone, acamprosate, disulfiram) per 10,000 individuals in each quarter between January 1, 2015, and December 31, 2021.

Results: There were 1179 and 451 individuals who received at least one prescription for OUD and AUD, respectively, in the first quarter of 2020. The prevalence of OUD medications more than doubled from 6.3 to 14.3 per 10,000 from January 1, 2015, to December 31, 2021. Likewise, AUD medication prevalence increased almost 10-fold from 0.68 to 6.5 per 10,000 from January 1, 2015, to December 31, 2021, primarily due to naltrexone. The incidence of AUD prescription use increased 8.6-fold from 0.29 to 2.51 per 10,000 during the study period. In contrast, the incidence of opioid agonist therapy declined from 2.1 per 10,000 in the first quarter of 2015 to 0.53 per 10,000 the first quarter of 2016, primarily due to methadone. Whereas methadone incidence declined, buprenorphine-naloxone incidence increased almost 15-fold during the study period.

Conclusion: An increase in both AUD medication prevalence and incidence in addition to an increase in buprenorphine-naloxone incidence was observed. These findings reflect an increase in the uptake of medications for treating AUD and OUD following changes to improve coverage and access to these medications.

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来源期刊
Journal of Addiction Medicine
Journal of Addiction Medicine 医学-药物滥用
CiteScore
6.10
自引率
9.10%
发文量
260
审稿时长
>12 weeks
期刊介绍: The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.
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