统一青少年骨肉瘤前期治疗范例。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-15 DOI:10.1089/jayao.2024.0054

Nicole P Daukshus, Viswatej Avutu, Emily Long Sarro, Michael D Kinnaman, Emily K Slotkin, Katherine Thornton, Mark A Dickson, Nancy T Sklarin, William D Tap, Julia Glade Bender

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引用次数: 0

摘要

目前，针对 15-39 岁青少年和年轻成人（AYA）患者简化癌症治疗的指导非常有限，因为目前的大部分数据都是从儿科或成人患者中推断出来的，这两种治疗模式之间可能存在很大差异。统一标准治疗方法有可能改善治疗效果，并为未来临床试验的发展奠定基础。我们介绍了纪念斯隆-凯特琳癌症中心（Memorial Sloan Kettering Cancer Center）的儿童和成人肉瘤服务部门在协调接受甲氨蝶呤、多柔比星和顺铂（MAP）治疗的青少年骨肉瘤患者的治疗和支持治疗方案方面的经验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Harmonization of the Upfront Osteosarcoma Treatment Paradigm for Adolescents and Young Adults.

Limited guidance exists on streamlining cancer therapy for adolescent and young adult (AYA) patients 15-39 years of age, as much of the current data are extrapolated from pediatric or adult counterparts and can differ significantly between the two care models. Harmonization of standard treatment approaches has the potential to improve outcomes and establish a foundation for the development of future clinical trials. We present our experience harmonizing treatment and supportive care regimens for AYA patients with osteosarcoma receiving treatment with methotrexate, doxorubicin, and cisplatin (MAP) therapy on the pediatric and adult sarcoma services at the Memorial Sloan Kettering Cancer Center.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.