滴答作响的大脑昼夜节律是大脑保护的新目标

IF 7.8 1区医学 Q1 CLINICAL NEUROLOGY Stroke Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI:10.1161/STROKEAHA.124.046684

Shuaili Xu, Milan Jia, Jiaqi Guo, Jiachen He, Xi Chen, Yi Xu, Wenbo Hu, Di Wu, Chuanjie Wu, Xunming Ji

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引用次数: 0

摘要

昼夜节律是在全身几乎所有类型细胞中观察到的一个主过程，它宏观调控着日常生理。最近的临床试验揭示了昼夜节律变化对急性缺血性中风的发病率、病理生理过程和预后的影响。此外，昼夜节律的细胞自主起搏器--核心时钟基因，在缺血/再灌注的相同病理生理过程后，会以非平行的方式影响神经血管单元组成细胞。在本综述中，我们将讨论昼夜节律和时钟基因在急性缺血性脑卒中病理生理过程中对各类神经血管单元细胞的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ticking Brain: Circadian Rhythm as a New Target for Cerebroprotection.

Circadian rhythm is a master process observed in nearly every type of cell throughout the body, and it macroscopically regulates daily physiology. Recent clinical trials have revealed the effects of circadian variation on the incidence, pathophysiological processes, and prognosis of acute ischemic stroke. Furthermore, core clock genes, the cell-autonomous pacemakers of the circadian rhythm, affect the neurovascular unit-composing cells in a nonparallel manner after the same pathophysiological processes of ischemia/reperfusion. In this review, we discuss the influence of circadian rhythms and clock genes on each type of neurovascular unit cell in the pathophysiological processes of acute ischemic stroke.

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来源期刊

Stroke 医学-临床神经学

CiteScore

13.40

自引率

6.00%

发文量

2021

审稿时长

3 months

期刊介绍： Stroke is a monthly publication that collates reports of clinical and basic investigation of any aspect of the cerebral circulation and its diseases. The publication covers a wide range of disciplines including anesthesiology, critical care medicine, epidemiology, internal medicine, neurology, neuro-ophthalmology, neuropathology, neuropsychology, neurosurgery, nuclear medicine, nursing, radiology, rehabilitation, speech pathology, vascular physiology, and vascular surgery. The audience of Stroke includes neurologists, basic scientists, cardiologists, vascular surgeons, internists, interventionalists, neurosurgeons, nurses, and physiatrists. Stroke is indexed in Biological Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts, CINAHL, Current Contents, Embase, MEDLINE, and Science Citation Index Expanded.