D Viet Anh, N Thanh Van Anh, N Ha Khuong, D V He, N Duy Hung
{"title":"3.0 特斯拉弥散张量成像在脑干胶质瘤分级评估中的诊断性能。","authors":"D Viet Anh, N Thanh Van Anh, N Ha Khuong, D V He, N Duy Hung","doi":"10.7417/CT.2024.5070","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the role of 3 Tesla Dif-fusion tensor imaging (DTI) in the assessment of brainstem glioma (BSG) grading.</p><p><strong>Materials and methods: </strong>The study comprised 22 patients, including pathology-proven 6 brainstem low-grade gliomas (BS-LGG) and 16 brainstem high-grade gliomas (BS-HGG). Characteristics including age, gender, fractional anisotropy (FA), mean diffusivity (MD) of the tumor, peritumoral region, and the ratio of tumor FA to parenchymal FA, as well as tumor MD to parenchymal MD (rFA and rMD), were compared using Mann-Whitney U test, Shapiro-Wilk test, and Chi-square test. Receiver operating characteristic (ROC) curve analysis was used in the study to determine cut-off values and diagnostic values for grading brainstem gliomas (BSG) using diffusion tensor imaging (DTI).</p><p><strong>Results: </strong>Our study revealed no significant difference in age and gender between the BS-LGG and BS-HGG groups (p>0.05). Fractional anisotropy (FA) indices on DTI MRI were found to be highly valuable in grading BSG, with an area under the curve (AUC) of 0.958 - 0.979 when using cut-off values of tFA, pFA, rtFA, and rpFA at 0.318, 0.378, 0.424, and 0.517, respectively. Particularly, rtFA demonstrated the hi-ghest diagnostic value with a sensitivity (Se) of 100%, specificity (Sp) of 93.8%, and AUC of 0.079. Conversely, the indices of tumor mean diffusivity (tMD), peritumoral edema region mean diffusivity (pMD), rtMD, and rpMD showed no diagnostic value in grading BSG.</p><p><strong>Conclusion: </strong>The fractional anisotropy (FA) value on DTI between the tumor region and normal brain parenchyma holds significant value in diagnosing brainstem gliomas (BSG) grading, thereby playing a crucial role in treatment planning and predicting outcomes for patients with brainstem gliomas.</p>","PeriodicalId":50686,"journal":{"name":"Clinica Terapeutica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic performance of 3.0 Tesla diffusion tensor imaging in the assessment of brain stem glioma grading.\",\"authors\":\"D Viet Anh, N Thanh Van Anh, N Ha Khuong, D V He, N Duy Hung\",\"doi\":\"10.7417/CT.2024.5070\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aimed to investigate the role of 3 Tesla Dif-fusion tensor imaging (DTI) in the assessment of brainstem glioma (BSG) grading.</p><p><strong>Materials and methods: </strong>The study comprised 22 patients, including pathology-proven 6 brainstem low-grade gliomas (BS-LGG) and 16 brainstem high-grade gliomas (BS-HGG). Characteristics including age, gender, fractional anisotropy (FA), mean diffusivity (MD) of the tumor, peritumoral region, and the ratio of tumor FA to parenchymal FA, as well as tumor MD to parenchymal MD (rFA and rMD), were compared using Mann-Whitney U test, Shapiro-Wilk test, and Chi-square test. Receiver operating characteristic (ROC) curve analysis was used in the study to determine cut-off values and diagnostic values for grading brainstem gliomas (BSG) using diffusion tensor imaging (DTI).</p><p><strong>Results: </strong>Our study revealed no significant difference in age and gender between the BS-LGG and BS-HGG groups (p>0.05). Fractional anisotropy (FA) indices on DTI MRI were found to be highly valuable in grading BSG, with an area under the curve (AUC) of 0.958 - 0.979 when using cut-off values of tFA, pFA, rtFA, and rpFA at 0.318, 0.378, 0.424, and 0.517, respectively. Particularly, rtFA demonstrated the hi-ghest diagnostic value with a sensitivity (Se) of 100%, specificity (Sp) of 93.8%, and AUC of 0.079. Conversely, the indices of tumor mean diffusivity (tMD), peritumoral edema region mean diffusivity (pMD), rtMD, and rpMD showed no diagnostic value in grading BSG.</p><p><strong>Conclusion: </strong>The fractional anisotropy (FA) value on DTI between the tumor region and normal brain parenchyma holds significant value in diagnosing brainstem gliomas (BSG) grading, thereby playing a crucial role in treatment planning and predicting outcomes for patients with brainstem gliomas.</p>\",\"PeriodicalId\":50686,\"journal\":{\"name\":\"Clinica Terapeutica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinica Terapeutica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7417/CT.2024.5070\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinica Terapeutica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7417/CT.2024.5070","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Diagnostic performance of 3.0 Tesla diffusion tensor imaging in the assessment of brain stem glioma grading.
Purpose: This study aimed to investigate the role of 3 Tesla Dif-fusion tensor imaging (DTI) in the assessment of brainstem glioma (BSG) grading.
Materials and methods: The study comprised 22 patients, including pathology-proven 6 brainstem low-grade gliomas (BS-LGG) and 16 brainstem high-grade gliomas (BS-HGG). Characteristics including age, gender, fractional anisotropy (FA), mean diffusivity (MD) of the tumor, peritumoral region, and the ratio of tumor FA to parenchymal FA, as well as tumor MD to parenchymal MD (rFA and rMD), were compared using Mann-Whitney U test, Shapiro-Wilk test, and Chi-square test. Receiver operating characteristic (ROC) curve analysis was used in the study to determine cut-off values and diagnostic values for grading brainstem gliomas (BSG) using diffusion tensor imaging (DTI).
Results: Our study revealed no significant difference in age and gender between the BS-LGG and BS-HGG groups (p>0.05). Fractional anisotropy (FA) indices on DTI MRI were found to be highly valuable in grading BSG, with an area under the curve (AUC) of 0.958 - 0.979 when using cut-off values of tFA, pFA, rtFA, and rpFA at 0.318, 0.378, 0.424, and 0.517, respectively. Particularly, rtFA demonstrated the hi-ghest diagnostic value with a sensitivity (Se) of 100%, specificity (Sp) of 93.8%, and AUC of 0.079. Conversely, the indices of tumor mean diffusivity (tMD), peritumoral edema region mean diffusivity (pMD), rtMD, and rpMD showed no diagnostic value in grading BSG.
Conclusion: The fractional anisotropy (FA) value on DTI between the tumor region and normal brain parenchyma holds significant value in diagnosing brainstem gliomas (BSG) grading, thereby playing a crucial role in treatment planning and predicting outcomes for patients with brainstem gliomas.
期刊介绍:
La Clinica Terapeutica è una rivista di Clinica e Terapia in Medicina e Chirurgia, fondata nel 1951 dal Prof. Mariano Messini (1901-1980), Direttore dell''Istituto di Idrologia Medica dell''Università di Roma “La Sapienza”. La rivista è pubblicata come “periodico bimestrale” dalla Società Editrice Universo, casa editrice fondata nel 1945 dal Comm. Luigi Pellino. La Clinica Terapeutica è indicizzata su MEDLINE, INDEX MEDICUS, EMBASE/Excerpta Medica.