{"title":"梅毒呈上升趋势--需要替代疗法和疫苗","authors":"Maria Chiara Masone","doi":"10.1038/s41585-024-00916-5","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"21 8","pages":"457-457"},"PeriodicalIF":12.1000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Syphilis on the rise — a need for alternative therapies and vaccines\",\"authors\":\"Maria Chiara Masone\",\"doi\":\"10.1038/s41585-024-00916-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":19088,\"journal\":{\"name\":\"Nature Reviews Urology\",\"volume\":\"21 8\",\"pages\":\"457-457\"},\"PeriodicalIF\":12.1000,\"publicationDate\":\"2024-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Urology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41585-024-00916-5\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41585-024-00916-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
由苍白螺旋体亚种（TPA）细菌引起的梅毒在二十一世纪再次成为全球健康问题，据报道，在过去二十年中，梅毒诊断病例急剧增加。注射长效苄星青霉素 G 是治疗梅毒的黄金标准，但患者人数的增加加上供应链能力有限，导致全球苄星青霉素短缺。第一篇文章是一篇通讯，作者评估了目前阿奇霉素耐药性的流行情况，以评估在苄星青霉素短缺的情况下，是否可以将这种大环内酯类抗生素（美国疾病控制与预防中心和加拿大目前的指南建议不使用这种抗生素）纳入梅毒替代疗法的讨论中。2017年至2023年期间，在美国13个州、华盛顿特区和加拿大两个州共采样了604株TPA菌株，并通过23S核糖体RNA亚基基因中是否存在A2058G或A2059G突变来评估阿奇霉素耐药性，这两种突变都会赋予阿奇霉素耐药性。总体而言，99.2%的抽样菌株（604株中的599株）对阿奇霉素具有基因型耐药性，其中584株（97.5%）和15株（2.5%）分别携带A2058G和A2059G突变。女性和与女性发生性关系的男性对阿奇霉素的耐药性也急剧上升（99.3%），而他们的耐药性历来较低（根据 2007 年至 2009 年期间获得的数据，耐药性为 14%）。这项研究中的患者在北美梅毒患者中具有代表性。总之，作者认为这些数据并不支持使用阿奇霉素，临床医生应考虑在苄星青霉素G短缺的情况下，在非怀孕患者中使用其他解决方案（强力霉素或头孢曲松）。
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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