人类胎儿喉返神经的发育和横截面形态。

IF 1.4 Q3 ANATOMY & MORPHOLOGY Anatomy & Cell Biology Pub Date : 2024-09-30 Epub Date: 2024-07-17 DOI:10.5115/acb.24.052
Maria Cecília Baratela, William Paganini Mayer, Josemberg da Silva Baptista
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引用次数: 0

摘要

喉返神经是迷走神经的双侧分支,主要与喉固有肌的运动神经支配有关。尽管喉返神经呈双侧分布,但由于与主动脉弓发育有关的胚胎过程,左右喉返神经的长度不等。这种长度不对称导致了有关形态学补偿的理论,以便为喉部固有肌肉提供对称的功能。在这项研究中,我们调查了人类胎儿喉返神经的发育和横截面形态计量学。研究使用了 15 个捐赠给解剖学和医学研究的死胎。胎儿的宫内年龄根据生物测量法估计为 30 至 40 周。对颈部内脏块进行了专门的解剖解剖,以制备喉返神经与喉接触点的组织学样本,并应用形态定量技术评估喉返神经的会厌和神经周围间隙。结果表明,左右喉返神经的会厌和神经周围间隙的横截面形态没有统计学差异,但我们发现有证据表明,在宫内生活的30至40周期间,左侧喉返神经的会厌和神经周围间隙发育得更为成熟。我们的数据表明,这些神经正处于形态发育阶段,可能为出生后左侧喉返神经直径增大和髓鞘化奠定了基础。
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Development and cross-sectional morphology of the recurrent laryngeal nerves in human fetuses.

The recurrent laryngeal nerve is a bilateral branch of the vagus nerve that is mainly associated with the motor innervation of the intrinsic muscles of the larynx. Despite its bilateral distribution, the right and left recurrent laryngeal nerves display unequal length due to embryological processes related to the development of the aortic arches. This length asymmetry leads to theories about morphological compensations to provide symmetrical functions to the intrinsic muscles of the larynx. In this study we investigated the developmental and cross-sectional morphometrics of the recurrent laryngeal nerves in human fetuses. Fifteen stillbirth fetuses donated to anatomical and medical research were used for investigation. Fetuses had intrauterine age ranging from 30 to 40 weeks estimated by biometry methods. Specialized anatomical dissection of the visceral block of the neck was performed to prepare histological samples of the recurrent laryngeal nerves in its point of contact with the larynx, and morpho-quantitative techniques were applied to evaluate the epineurium and perineural space of the recurrent laryngeal nerves. No statistical difference in the cross-sectional morphology of the epineurium and perineural space between right and left recurrent laryngeal nerves intra-individually was confirmed, however, we found evidence that these structures are under greater development in the left recurrent laryngeal nerve during 30 to 40 weeks of intrauterine life. Our data suggest that the nerves are under morphological development that possibly set the stage for accommodation of larger diameter and myelinization of the left recurrent laryngeal nerve during post-natal life.

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来源期刊
Anatomy & Cell Biology
Anatomy & Cell Biology ANATOMY & MORPHOLOGY-
CiteScore
1.80
自引率
9.10%
发文量
75
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