Preserflo® 在真实世界中的中期生存结果:两年回顾性分析

IF 2 4区 医学 Q2 OPHTHALMOLOGY Journal of Glaucoma Pub Date : 2024-11-01 Epub Date: 2024-07-17 DOI:10.1097/IJG.0000000000002459
Afonso Lima-Cabrita, Miguel Santos, Patrícia José, Rafael Barão, André Barata, Luís Abegão Pinto
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引用次数: 0

摘要

Prcis:目的:评估 Preserflo® 滤波手术的中期存活率和安全性:方法:回顾性队列研究。纳入了 2019 年 12 月至 2021 年 4 月期间接受标准化 Preserflo® 植入术和丝裂霉素 C 的连续患者。临床数据取自患者病历。根据世界青光眼协会指南,主要结果是24个月的手术存活率。存活率采用卡普兰-梅尔统计法进行评估。分析以眼球为单位进行,并采用意向治疗法:本研究共纳入 95 只眼睛(18 例合并白内障手术)。超过一半的病例(n=51)为原发性开角型青光眼,超过五分之一的病例曾接受过青光眼滤过手术。二十四个月后的眼压与基线相比明显下降(22.4±6.28 mmHg vs 12.0±3.43 mmHg),降眼压药物的需求也明显降低(2.88 (±0.92) vs 0.79 (±1.3), PC结论:Preserflo ®滤过手术能有效地将眼压降至 "低十分之一",并具有足够的手术存活率和安全性。在单独手术和术前眼压较高(≥21 mmHg)的情况下,手术存活率最高。
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Midterm Survival Results of Preserflo in a Real-World Setting.

Prcis: Preserflo surgery is a safe procedure, effective in reducing intraocular pressure into the "low teens," surgical survival is greatest in cases of high baseline intraocular pressure (above 21 mm Hg) and when performed as a standalone procedure.

Purpose: To evaluate midterm surgical survival and safety profile of Preserflo filtering surgery.

Methods: In this retrospective, cohort study, consecutive patients who underwent standardized Preserflo implantation with mitomycin C from December 2019 to April 2021 were included. Clinical data were retrieved from patient charts. The primary outcome was surgical survival at 24 months in accordance with World Glaucoma Association guidelines. Survival was evaluated using Kaplan-Meier statistics. Analysis was performed at the eye level and as intention to treat.

Results: Ninety-five eyes were included in this study (18 cases combined with cataract surgery). More than half of cases (n=51) were primary open angle glaucoma, with over a fifth having a prior filtering glaucoma procedure. Intraocular pressure at 24 months was significantly decreased from baseline (22.4±6.28 vs. 12.0±3.43 mm Hg), as well as the need for IOP-lowering medication [2.88 (±0.92) vs. 0.79 (±1.3), P <0.001 all comparisons]. Standalone Preserflo achieved a qualified survival (irrespective of medication) of 71% (95% CI, 62%-83%) and 44% (95% CI, 27%-75%) in the combined procedure subgroup ( P <0.05 when considering absolute survival). Eyes with baseline intraocular pressure ≥21 mm Hg showed a greater qualified survival when compared with eyes with baseline ≤18 mm Hg [80% (95% CI, 65%-100%) vs. 50% (95% CI, 32%-76%); P <0.05]. Intra and early operative complications were few, self-limited, and did not require surgical management. The reoperation rate was low (18%).

Conclusions: Preserflo filtering surgery was effective in reducing intraocular pressure into the "low teens" and presents an adequate surgical survival and safety profile. Surgical survival appeared greatest when performed as standalone and when preoperative intraocular pressure was high.

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来源期刊
Journal of Glaucoma
Journal of Glaucoma 医学-眼科学
CiteScore
4.20
自引率
10.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.
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