肝素结合诱导过二亚胺双拉双亲化合物自组装的超分子手性。

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Journal of Materials Chemistry B Pub Date : 2024-07-02 DOI:10.1039/D4TB00862F

Poonam Sharma, Akhil Venugopal, Claudia Martínez Verdi, Mauri Serra Roger, Annalisa Calò and Mohit Kumar

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引用次数: 0

摘要

手性是生物大分子的标志之一。在这里，我们利用肝素这种手性生物大分子和强效药物，诱导手性组织组装成非手性分子。多阴离子肝素与二阳离子过二亚胺衍生物结合，在水介质和高竞争性细胞培养基中诱导超分子螺旋组织。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Heparin binding induced supramolecular chirality into the self-assembly of perylenediimide bolaamphiphile†

Chirality is one of the hallmarks of biomolecules. Herein, we utilize heparin, a chiral biomolecule and potent drug, to induce chiral organization into the assembly of an achiral molecule. Polyanionic heparin binds with a dicationic perylenediimide derivative to induce supramolecular helical organization in aqueous medium as well as in a highly competitive cell culture medium.

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices

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