[胃肠胰神经内分泌肿瘤的组织和分子病理学]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI:10.1055/a-2157-5460
Franziska Kellers, Dominik Maria Schulte, Moritz Jesinghaus, Björn Konukiewitz
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引用次数: 0

摘要

根据世界卫生组织基于形态学标准的分类,神经内分泌肿瘤可分为神经内分泌肿瘤、神经内分泌癌和神经内分泌-非神经内分泌混合肿瘤。神经内分泌肿瘤是一种分化良好的肿瘤,具有特定部位的组织学和分子特征,这对临床治疗非常重要。在涉及转移的病例中,病理学通常可以通过少量免疫组化标记物来帮助鉴别原发肿瘤。神经内分泌癌是分化较差的肿瘤。它们又分为小细胞型和大细胞型神经内分泌癌。神经内分泌癌和神经内分泌-非神经内分泌混合瘤的分子特征与传统腺癌关系密切,并具有特定部位的特征。神经内分泌癌和神经内分泌-非神经内分泌混合瘤的分子分析尚未完全纳入日常诊断中,主要是在精准肿瘤学的背景下进行。
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[Histo- and molecular pathology in gastroenteropancreatic neuroendocrine neoplasms].

Neuroendocrine neoplasms are classified according to the WHO classification based on morphological criteria into neuroendocrine tumors, neuroendocrine carcinomas, and mixed neuroendocrine-non-neuroendocrine neoplasms. Neuroendocrine tumors are well differentiated neoplasms and show characteristic site-specific histological and molecular features, which is important for their clinical management. In cases dealing with metastasis, pathology often can help to identify the primary tumors using a small immunohistochemical marker panel. Neuroendocrine carcinomas are poorly differentiated neoplasms. They are subdivided into neuroendocrine carcinomas of small cell and large cell type. The molecular profile of neuroendocrine carcinomas and mixed neuroendocrine-non-neuroendocrine neoplasms shows a close relationship to conventional adenocarcinomas with site-specific features. Molecular analysis of neuroendocrine carcinomas and neuroendocrine-non-neuroendocrine neoplasms are not yet fully integrated in daily diagnostics and are mainly performed in the context of precision oncology.

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