Brett P Ransegnola, Tanyaporn Pattarabanjird, Coleen A McNamara
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引用次数: 0
摘要
动脉粥样硬化是一种慢性炎症性疾病,其进展受到促炎物质的刺激和抗炎介质的限制。氧化损伤和作为损伤相关分子模式的氧化特异性表位的产生具有高度炎症性,而 B-1 和边缘区 B 细胞产生的 IgM 抗体通过中和并促进清除这些促炎症信号来对抗无限制的炎症。在这篇综述中,我们将重点描述小鼠和人类中产生 IgM 的 B 细胞的特性,阐述产生 IgM 的机制,并讨论增强产生动脉粥样硬化保护性 IgM 的潜在策略。此外,我们还将讨论对人类有前景的治疗干预措施,以帮助增强 IgM 的产生并提供动脉粥样硬化保护。
Tipping the Scale: Atheroprotective IgM-Producing B Cells in Atherosclerosis.
Atherosclerosis is a chronic inflammatory disease whose progression is fueled by proinflammatory moieties and limited by anti-inflammatory mediators. Whereas oxidative damage and the generation of oxidation-specific epitopes that act as damage-associated molecular patterns are highly inflammatory, IgM antibodies produced by B-1 and marginal zone B cells counteract unrestricted inflammation by neutralizing and encouraging clearance of these proinflammatory signals. In this review, we focus on describing the identities of IgM-producing B cells in both mice and humans, elaborating the mechanisms underlying IgM production, and discussing the potential strategies to augment the production of atheroprotective IgM. In addition, we will discuss promising therapeutic interventions in humans to help tip the scale toward augmentation of IgM production and to provide atheroprotection.
期刊介绍:
The journal "Arteriosclerosis, Thrombosis, and Vascular Biology" (ATVB) is a scientific publication that focuses on the fields of vascular biology, atherosclerosis, and thrombosis. It is a peer-reviewed journal that publishes original research articles, reviews, and other scholarly content related to these areas. The journal is published by the American Heart Association (AHA) and the American Stroke Association (ASA).
The journal was published bi-monthly until January 1992, after which it transitioned to a monthly publication schedule. The journal is aimed at a professional audience, including academic cardiologists, vascular biologists, physiologists, pharmacologists and hematologists.