小胶质细胞介导了与高环境温度相关的慢波睡眠的增加。

IF 2.6 4区医学 Q2 PHYSIOLOGY Journal of Physiological Sciences Pub Date : 2024-07-17 DOI:10.1186/s12576-024-00929-0

Sena Hatori, Futaba Matsui, Zhiwen Zhou, Hiroaki Norimoto

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引用次数: 0

摘要

环境温度升高会导致睡眠增加。然而，这一现象背后的机制仍然未知。本研究旨在探讨小胶质细胞在环境温度升高导致睡眠增加中的作用。我们证实，在35 °C时，慢波睡眠比在25 °C时明显增加。值得注意的是，在使用可消耗小胶质细胞的CSF1R抑制剂PLX3397处理后，这种效应消失了，而25 °C时的睡眠量则不受影响。这些观察结果表明，小胶质细胞在调节睡眠的平衡调节以应对环境温度波动方面起着关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microglia mediate the increase in slow-wave sleep associated with high ambient temperature.

An increase in ambient temperature leads to an increase in sleep. However, the mechanisms behind this phenomenon remain unknown. This study aimed to investigate the role of microglia in the increase of sleep caused by high ambient temperature. We confirmed that at 35 °C, slow-wave sleep was significantly increased relative to those observed at 25 °C. Notably, this effect was abolished upon treatment with PLX3397, a CSF1R inhibitor that can deplete microglia, while sleep amount at 25 °C was unaffected. These observations suggest that microglia play a pivotal role in modulating the homeostatic regulation of sleep in response to the fluctuations in ambient temperature.

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来源期刊

Journal of Physiological Sciences 医学-生理学

CiteScore

4.40

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.