肿瘤微环境中的活性氧:利用免疫原性细胞死亡。

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-15 DOI:10.1016/j.bbcan.2024.189154
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引用次数: 0

摘要

肿瘤微环境(TME)是一个动态的复杂系统,其网络结构不断发生变化,特别是影响氧化还原平衡。这些变化共同形成了一个多样化的生态系统,通过影响肿瘤微环境的细胞和分子成分,积极支持肿瘤的进展。尽管癌症免疫疗法在临床上取得了令人瞩目的进展,但其临床应用范围仍受到 TME 改变和肿瘤免疫原性不足的限制。最近的研究发现,一些常规和靶向治疗策略可以增强免疫疗法的疗效,即使是免疫原性较低的实体瘤患者也不例外。这些策略通过依赖于 ROS 的损伤相关分子模式(DAMPs)的释放,引发免疫原性细胞死亡(ICD)。这些 DAMPs 可识别免疫细胞上的模式识别受体(PRRs)并与之结合,激活和成熟防御细胞,最终产生强大的抗肿瘤免疫反应。本综述强调了氧化还原平衡在协调 TME 从冷表型向热表型转变中的关键作用,以及 ROS-ICD 轴在诱导免疫反应中的关键作用。此外,它还提供了关于利用 ROS 生成诱导 ICD 的策略的最新见解。综合分析旨在为免疫原性较低的肿瘤开发基于 ROS 的有效癌症免疫疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Reactive oxygen species of tumor microenvironment: Harnessing for immunogenic cell death

The tumor microenvironment (TME) is a dynamic and complex system that undergoes continuous changes in its network architecture, notably affecting redox homeostasis. These alterations collectively shape a diverse ecosystem actively supporting tumor progression by influencing the cellular and molecular components of the TME. Despite the remarkable clinical advancements in cancer immunotherapy, its spectrum of clinical utility is limited by the altered TME and inadequate tumor immunogenicity. Recent studies have revealed that some conventional and targeted therapy strategies can augment the efficacy of immunotherapy even in patients with less immunogenic solid tumors. These strategies provoke immunogenic cell death (ICD) through the ROS-dependent liberation of damage-associated molecular patterns (DAMPs). These DAMPs recognize and bind with Pattern Recognition Receptors (PRRs) on immune cells, activating and maturing defense cells, ultimately leading to a robust antitumor immune response. The present review underscores the pivotal role of redox homeostasis in orchestrating the transition of TME from a cold to a hot phenotype and the ROS-ICD axis in immune response induction. Additionally, it provides up-to-date insights into strategies that leverage ROS generation to induce ICD. The comprehensive analysis aims to develop ROS-based effective cancer immunotherapies for less immunogenic tumors.

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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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