Diabetic nephropathy: Ayur-nutri-pharmaco approach

Prameha, described in Ayurveda, shares similarities with non-communicable lifestyle disorder Diabetes Mellitus. It is associated with an array of complications, referred to as “Upadrava” which can manifest in various organ systems. Among the complications, diabetic nephropathy (DN) stands out as a critical concern due to its impact on kidney health. Ayurveda views the body as an interplay of Doshas, and diabetes-related nephropathy is understood through the lens of “Prameha upadrava” which involves an imbalance of Doshas affecting kidney function. Ayurvedic treatment emphasizes personalized dietary adjustments, herbal remedies, lifestyle modifications, and mind-body practices, wherein the Modern therapeutic approaches include receptor mediated targeting, stem cell therapies, and dietary management. The current review aims for better insights, amalgamating the ailments and divergence between Ayurvedic and pharmacological perspectives on pathophysiology and management of DN. A dedicated effort has been initiated to identify the specific edible botanical elements mentioned as Pramehaghna in the Ayurvedic compendium, Bhavaprakash nighantu. A comprehensive evaluation of botanical entities was performed for a deeper understanding of their enumerated properties. The data pave newer avenues toward multidimensional-holistic approach to address the intricate complexities of DN leading to integrated approaches in Ayurveda, nutrition and pharmacology leading to better health and hygiene.