影响冠状动脉疾病严重程度的新可调节风险因素

IF 4.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Molecular Sciences Pub Date : 2024-07-16 DOI:10.3390/ijms25147766
Kamila Florek, Maja Kübler, Magdalena Górka, Piotr Kübler
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引用次数: 0

摘要

心血管疾病(CVDs)仍然是导致全球死亡的主要原因,而冠状动脉疾病(CAD)则是其中的罪魁祸首。就 CAD 而言,其存在与否以及严重程度都会对患者的治疗和预后产生影响。CAD 的复杂程度可以用 SYNTAX 评分(SS)这一指标来评估。在短期和长期观察中,SS 越高,主要不良心血管事件(MACE)的发生率就越高。因此,根据SS评分结果确定影响CAD严重程度的风险因素,有助于降低已患CAD患者的风险,减少其对冠状动脉粥样硬化进展的影响。已确立的 CAD 危险因素与冠状动脉斑块负荷相关的危险因素是一致的。然而,最近有研究表明,我们在本文中介绍的一些新指标,如炎症参数、C 反应蛋白(CRP)、基于血涂片结果的比率和尿酸等,对 CAD 的复杂性有显著影响。此外,微生物群改变、维生素 D 缺乏和阻塞性睡眠呼吸暂停(OSA)也能预测 CAD 的严重程度。不过,有时某些指标仅对慢性冠状动脉综合征(CCS)或特定急性冠状动脉综合征(ACS)有显著意义。重要的是,有必要将跨学科和转化方法应用到新型的冠状动脉粥样硬化严重程度风险评估中,以最大限度地提高冠状动脉粥样硬化进展风险患者的二级预防效果。
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New Modifiable Risk Factors Influencing Coronary Artery Disease Severity
Cardiovascular diseases (CVDs) remain the leading cause of death worldwide with coronary artery disease (CAD) being the first culprit in this group. In terms of CAD, not only its presence but also its severity plays a role in the patient’s treatment and prognosis. CAD complexity can be assessed with the indicator named the SYNTAX score (SS). A higher SS is associated with major adverse cardiovascular event (MACE) occurrence in short- and long-term observations. Hence, the risk factors affecting CAD severity based on SS results may help lower the risk among patients with already developed CAD to reduce their impact on coronary atherosclerosis progression. The well-established risk factors of CAD are consistent with those associated with the coronary plaque burden. However, recently, it was shown that new indicators exist, which we present in this paper, that significantly contribute to CAD complexity such as inflammatory parameters, C-reactive protein (CRP), ratios based on blood smear results, and uric acid. Moreover, microbiota alteration, vitamin D deficiency, and obstructive sleep apnea (OSA) also predicted CAD severity. However, sometimes, certain indicators were revealed as significant only in terms of chronic coronary syndromes (CCSs) or specific acute coronary syndromes (ACSs). Importantly, there is a need to apply the interdisciplinary and translational approach to the novel CAD severity risk assessment to maximize the impact of secondary prevention among patients at risk of coronary atherosclerosis progression.
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来源期刊
International Journal of Molecular Sciences
International Journal of Molecular Sciences Chemistry-Organic Chemistry
CiteScore
8.10
自引率
10.70%
发文量
13472
审稿时长
17.49 days
期刊介绍: The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).
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