血小板储存--问题、改进和新视角

IF 4.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Molecular Sciences Pub Date : 2024-07-16 DOI:10.3390/ijms25147779
Natalia Trochanowska-Pauk, Tomasz Walski, R. Bohara, Julia Mikolas, Krystian Kubica
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引用次数: 0

摘要

输注血小板是临床治疗中的常规程序,目的是防止癌症、手术或外伤等危重病人出血。然而,血小板是易受影响的血细胞,需要特定的储存条件。由于各种因素,包括细菌污染的风险以及被称为血小板储存病变的物理和功能变化的发生,血小板浓缩物的可用性被限制在五天之内。本文根据研究领域的不同,将与血小板储存病变相关的问题分为四类:储存条件、添加剂解决方案、血小板新检测方法(蛋白质组学和代谢组学分析)以及血小板生产的广泛数据建模(数学建模、统计分析和人工智能)。本文提供了有关血小板储存的挑战、潜在改进和新观点的广泛信息。
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Platelet Storage—Problems, Improvements, and New Perspectives
Platelet transfusions are routine procedures in clinical treatment aimed at preventing bleeding in critically ill patients, including those with cancer, undergoing surgery, or experiencing trauma. However, platelets are susceptible blood cells that require specific storage conditions. The availability of platelet concentrates is limited to five days due to various factors, including the risk of bacterial contamination and the occurrence of physical and functional changes known as platelet storage lesions. In this article, the problems related to platelet storage lesions are categorized into four groups depending on research areas: storage conditions, additive solutions, new testing methods for platelets (proteomic and metabolomic analysis), and extensive data modeling of platelet production (mathematical modeling, statistical analysis, and artificial intelligence). This article provides extensive information on the challenges, potential improvements, and novel perspectives regarding platelet storage.
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来源期刊
International Journal of Molecular Sciences
International Journal of Molecular Sciences Chemistry-Organic Chemistry
CiteScore
8.10
自引率
10.70%
发文量
13472
审稿时长
17.49 days
期刊介绍: The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).
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