Y. Karanga, Têeda Hamidou Ganamé, Wende-Konté Hazael Conania Nikiema, I. Tapsoba
{"title":"使用α-葡萄糖苷酶抑制剂研究布基纳法索大戟科植物大戟的提取物的抗糖尿病活性","authors":"Y. Karanga, Têeda Hamidou Ganamé, Wende-Konté Hazael Conania Nikiema, I. Tapsoba","doi":"10.9734/irjpac/2024/v25i4865","DOIUrl":null,"url":null,"abstract":"Euphorbia hirta L. is an herbaceous plant used in traditional medicine to treat several diseases. In the present work, different fractions of Euphorbia hirta L. hydroalcoholic extract were investigated for their anti-diabetic properties on α-glucosidase’s inhibition activities. Chemical screening realized following Folin-Ciocalteu and AlCl3 methods showed that ethyl acetate (AcOET) and butanol (BuOH) extracts contain 432.687 ± 1.832 µg and 332.433 ± 1.255 µg GAE/mg of extract for phenolic compounds. The same extracts contained high levels of total flavonoids estimated at 417.850 ± 15.941 µg and 227.640 ± 2.657 μg QE/mg of extract respectively. The anti-diabetic activities revealed that AcOET and BuOH have a very significant inhibitory potential on the enzymatic activity of α-glucosidase with an IC50 values of 1.295 ± 0.035 μg/mL and 2.188 ± 0.204 μg/mL respectively compared to acarbose (IC50 = 214.825 ± 3.816 μg/mL).","PeriodicalId":14371,"journal":{"name":"International Research Journal of Pure and Applied Chemistry","volume":"27 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anti-Diabetic Activities of the Extracts from Euphorbia hirta L. (Euphorbiaceae) Specie found in Burkina Faso Using α-Glucosidase Inhibitor\",\"authors\":\"Y. Karanga, Têeda Hamidou Ganamé, Wende-Konté Hazael Conania Nikiema, I. Tapsoba\",\"doi\":\"10.9734/irjpac/2024/v25i4865\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Euphorbia hirta L. is an herbaceous plant used in traditional medicine to treat several diseases. In the present work, different fractions of Euphorbia hirta L. hydroalcoholic extract were investigated for their anti-diabetic properties on α-glucosidase’s inhibition activities. Chemical screening realized following Folin-Ciocalteu and AlCl3 methods showed that ethyl acetate (AcOET) and butanol (BuOH) extracts contain 432.687 ± 1.832 µg and 332.433 ± 1.255 µg GAE/mg of extract for phenolic compounds. The same extracts contained high levels of total flavonoids estimated at 417.850 ± 15.941 µg and 227.640 ± 2.657 μg QE/mg of extract respectively. The anti-diabetic activities revealed that AcOET and BuOH have a very significant inhibitory potential on the enzymatic activity of α-glucosidase with an IC50 values of 1.295 ± 0.035 μg/mL and 2.188 ± 0.204 μg/mL respectively compared to acarbose (IC50 = 214.825 ± 3.816 μg/mL).\",\"PeriodicalId\":14371,\"journal\":{\"name\":\"International Research Journal of Pure and Applied Chemistry\",\"volume\":\"27 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Research Journal of Pure and Applied Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.9734/irjpac/2024/v25i4865\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Research Journal of Pure and Applied Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/irjpac/2024/v25i4865","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anti-Diabetic Activities of the Extracts from Euphorbia hirta L. (Euphorbiaceae) Specie found in Burkina Faso Using α-Glucosidase Inhibitor
Euphorbia hirta L. is an herbaceous plant used in traditional medicine to treat several diseases. In the present work, different fractions of Euphorbia hirta L. hydroalcoholic extract were investigated for their anti-diabetic properties on α-glucosidase’s inhibition activities. Chemical screening realized following Folin-Ciocalteu and AlCl3 methods showed that ethyl acetate (AcOET) and butanol (BuOH) extracts contain 432.687 ± 1.832 µg and 332.433 ± 1.255 µg GAE/mg of extract for phenolic compounds. The same extracts contained high levels of total flavonoids estimated at 417.850 ± 15.941 µg and 227.640 ± 2.657 μg QE/mg of extract respectively. The anti-diabetic activities revealed that AcOET and BuOH have a very significant inhibitory potential on the enzymatic activity of α-glucosidase with an IC50 values of 1.295 ± 0.035 μg/mL and 2.188 ± 0.204 μg/mL respectively compared to acarbose (IC50 = 214.825 ± 3.816 μg/mL).
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