早期诊断帕金森病的生物标志物

F. Yusupov, A. Yuldashev, T. Nurmatov
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摘要

世界卫生组织(WHO)指出,神经退行性疾病将是未来最大的健康问题。在神经退行性疾病中,帕金森病是仅次于阿尔茨海默病的第二大常见疾病。帕金森病(Parkinson's disease,PD)是运动障碍患者最常见的病症。在神经系统疾病中,帕金森病具有很高的社会意义,因为它会对患者的生活质量产生负面影响(早期丧失工作能力、进行性运动和认知能力障碍)。随着预期寿命的延长,帕金森病的发病率也在增加。目前正在积极研究早期诊断帕金森病的生物标志物。本综述介绍了对临床前诊断帕金森病最有临床意义的生物标志物。文中讨论了帕金森病的脑脊液生物标志物、血清生物标志物和其他生物液体的生物标志物。
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Biomarkers of Early Diagnosis of Parkinson’s Disease
The World Health Organization (WHO) has stated that neurodegenerative diseases will be the biggest health problem in the future. Among neurodegenerative diseases, Parkinson’s disease is the second most common after Alzheimer’s disease. Parkinson’s disease (PD) is the most common pathology of a person with movement disorders. Among neurological diseases, it has a high social significance due to the negative effect on the quality of life (early loss of the ability to work, progressive disorders of motor and cognitive skills). With increasing life expectancy, the prevalence of Parkinson’s disease increases. Biological markers of early diagnosis of Parkinson’s disease are being actively studied. The review presents the most clinically significant biological markers for the preclinical diagnosis of Parkinson’s disease. Biomarkers of cerebrospinal fluid, serum biomarkers and biomarkers of other biological fluids in Parkinson's disease are discussed.
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