Psychological manifestations in patients with tuberculosis: prevalence and contributing factors

Tuberculosis (TB) continues to be a major global health concern impacting millions of people each year. Beyond its outward symptoms TB can have a significant negative influence on psychological health and cause psychological anguish in those who are afflicted. The purpose of this review is to recapitulate the frequency and contributing variables of psychological discomfort in TB patients. Previous studies show varying prevalence rates of psychological distress which frequently manifests as stress, worry, and depression. Numerous factors such as sociodemographic characteristics the severity of the disease the treatment plan, stigma, and social support. these factors can alter gene expression patterns, epigenetic modifications, and immune responses linked to higher psychological distress. Psychological factors like stress, anxiety, and depression can influence gene metabolism in TB patients through various mechanisms. These factors impacting TB susceptibility, disease progression, and treatment outcomes. To effectively address the mental health needs of TB patients, it is imperative to comprehend the prevalence and factors of psychological distress in tb population. Promote the holistic well-being of TB patients, it is imperative that mental health treatments be integrated into TB care in conjunction with initiatives to lessen stigma and enhance social support.