光激活微管靶向药物：推动结直肠癌疗法的发展

IF 5.5 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-07-14 DOI:10.3748/wjg.v30.i26.3257

Naresh Singh, Samantha Sharma

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引用次数: 0

摘要

多年来，免疫疗法明显改善了癌症治疗领域。然而，实现结直肠癌（CRC）患者的长期生存仍然是一个尚未满足的重大需求。结合了 MEK 或多激酶抑制剂等靶向药物的联合免疫疗法提供了一些缓解治疗效果。然而，目前针对 CRC 的治疗手段仍存在很大差距。近年来，人们对新型治疗策略的探索兴趣大增，其中包括结合光学设备应用光激活药物。这种方法有望实现细胞毒性药物（如微管靶向药物）的局部和靶向输送，直接作用于结肠内的癌细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer

Over the years immunotherapy has demonstrably improved the field of cancer treatment. However, achieving long-term survival for colorectal cancer (CRC) patients remains a significant unmet need. Combination immunotherapies incorporating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative benefit. Nevertheless, substantial gaps remain in the current therapeutic armamentarium for CRC. In recent years, there has been a surge of interest in exploring novel treatment strategies, including the application of light-activated drugs in conjunction with optical devices. This approach holds promise for achieving localized and targeted delivery of cytotoxic agents, such as microtubule-targeting drugs, directly to cancerous cells within the colon.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.