用于冠状动脉血管造影和全心肌灌注定量的超极化水

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Tomography Pub Date : 2024-07-13 DOI:10.3390/tomography10070084

Yupeng Zhao, M. Lerche, Magnus Karlsson, R. Olin, E. Hansen, Malene Aastrup, Mohsen Redda, C. Laustsen, Lars G. Hanson, J. Ardenkjær-Larsen

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引用次数: 0

摘要

目的：水可在细胞膜上自由扩散，因此适合测量组织的绝对灌注量。在本研究中，我们介绍了一种利用超极化水进行冠状动脉造影和量化整个心脏心肌灌注的成像方法。方法：利用紫外线产生的自由基通过溶解动态核极化（dDNP）对 1H 进行超极化。使用在舒张期选通的破坏 GRE（SPGRE）序列获取亚毫米分辨率的冠状动脉二维投影图像。动态血流灌注图像是通过多切片 SPGRE 获得的，该序列在舒张期选通，覆盖整个心脏。通过直方图分析灌注值，并将最常见的估计灌注值（分布模式）与文献中 15O 水 PET 的平均值进行比较。结果：注射时的液态极化为 10%，在 D2O TRIS 缓冲液中的 T1 为 30 秒。冠状动脉图像和动态灌注图像均显示出良好的质量。冠状动脉主干和细小分支均清晰分辨。最常见的估计灌注值约为 0.6 mL/g/min，低于文献中 15O 水 PET 的平均值（约为 1.1 和 1.5 mL/g/min）。结论该研究成功证明了使用超极化水实现高分辨率、无运动冠状动脉血管造影和三维全心定量心肌灌注的可行性。

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Hyperpolarized Water for Coronary Artery Angiography and Whole-Heart Myocardial Perfusion Quantification

Purpose: Water freely diffuses across cell membranes, making it suitable for measuring absolute tissue perfusion. In this study, we introduce an imaging method for conducting coronary artery angiography and quantifying myocardial perfusion across the entire heart using hyperpolarized water. Methods: 1H was hyperpolarized using dissolution dynamic nuclear polarization (dDNP) with UV-generated radicals. Submillimeter resolution coronary artery images were acquired as 2D projections using a spoiled GRE (SPGRE) sequence gated on diastole. Dynamic perfusion images were obtained with a multi-slice SPGRE with diastole gating, covering the entire heart. Perfusion values were analyzed through histograms, and the most frequent estimated perfusion value (the mode of the distribution), was compared with the average values for 15O water PET from the literature. Results: A liquid state polarization of 10% at the time of the injection and a 30 s T1 in D2O TRIS buffer were measured. Both coronary artery and dynamic perfusion images exhibited good quality. The main and small coronary artery branches were well resolved. The most frequent estimated perfusion value is around 0.6 mL/g/min, which is lower than the average values obtained from the literature for 15O-water PET (around 1.1 and 1.5 mL/g/min). Conclusion: The study successfully demonstrated the feasibility of achieving high-resolution, motion-free coronary artery angiography and 3D whole-heart quantitative myocardial perfusion using hyperpolarized water.

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.