北部肺动脉高压:一种被遗忘的肺循环病理学

Life Pub Date : 2024-07-13 DOI:10.3390/life14070875
D. Kosanovic, S. N. Avdeev, Andrey P. Milovanov, A. L. Chernyaev
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引用次数: 0

摘要

北肺动脉高压(NPH)是一种在非俄语国家仍很神秘的疾病。现存的文献大多是俄语版本,因此世界其他地区无法查阅。最近,人们越来越关注气候变化和环境对肺循环的影响,这促使我们总结过去有关寒冷对肺血管影响的知识。在这篇综述中,我们首次用英语详细描述了人类 NPH 的病理特征,这是一种发生在极寒地区人群中的医学疾病。简而言之,NPH 的特点是肺动脉肌肉化和动脉血管新生肌肉化,最终发展为右心室肥大。然而,NPH 病理的深层分子机制有待今后的全面研究来揭示。
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Northern Pulmonary Hypertension: A Forgotten Kind of Pulmonary Circulation Pathology
Northern pulmonary hypertension (NPH) is a medical condition that is still enigmatic in non-Russian-speaking countries. The extant previous literature is mostly available in the Russian language and, therefore, not accessible to the rest of the world. The recent increased interest in climate changes and environmental effects on pulmonary circulation prompted us to summarize the knowledge from the past about the effects of cold on pulmonary vasculature. In this review, we, for the first time, describe, in detail, the pathological attributes of human NPH, a medical disorder that occurs in people living in extremely cold regions, in the English language. Briefly, NPH is characterized by the hyper-muscularization of the pulmonary arteries and de novo muscularization of the arterioles with the ultimate development of right ventricular hypertrophy. However, the profound molecular mechanisms of the NPH pathology are to be revealed in future comprehensive studies.
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