Epigenetic and Mental Diseases: The Role of Psychotherapy

It is well known that mental illness is often the result of genetic susceptibility combined with environmental factors. In this context, it is useful to consider the role that changes in DNA expression, known as epigenetic, can play in the development and progression of psychiatric disorders. Accordingly, psychotherapy, a form of pharmacological strategy that often targets dysfunctional emotions and behaviors, may also improve the symptoms of mental illness via epigenetic changes. This article reviews the current literature on epigenetic changes induced by psychotherapy in psychiatric disorders, pointing out encouraging findings for borderline personality disorder (BPD), post-traumatic stress disorder (PTSD), anxiety disorders and obsessive–compulsive disorder (OCD). It focuses on genes that are more commonly associated with epigenetic changes and paves the way for further research.