J. Keerthana, K.H.I.K. Hewavitharana, K.B. Wijesekara
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引用次数: 0
摘要
摘要 人体骨骼是羟基磷灰石(HA)和胶原蛋白的复合材料。HA(Ca10(PO4)6(OH)2)是一种钙磷比例与天然骨成分相似的生物材料。本研究采用聚乳酸(PLA)作为聚合物基体,马来酸酐(MAH)作为相容剂,从牛骨中提取的天然 HA(BHA)作为具有良好表面特性的合适机械支撑填料,制备了复合材料。通过 900 ℃ 下的热分解法制备了不同 HA(10-30 wt.%)、聚乳酸(PLA)和有或无 MAH(0.5-8 wt.%)的复合材料。通过 X 射线衍射 (XRD)、傅立叶变换红外光谱 (FTIR)、热重分析 (TGA)、扫描电子显微镜 (SEM) 和拉伸强度测量,分析了聚乳酸和 MAH 对 BHA 的形态、热和机械性能的影响。结果表明,含 30 重量百分比 HA、66 重量百分比 PLA 和 4 重量百分比 MAH 的 HA30/PLA/4MAH 复合材料的平均拉伸强度最大,达到 307.71 兆帕。总体结果从力学角度证实了 MAH 相容剂在骨组织工程 HA/PLA/MAH 复合材料中的作用。
Synthesis and characterization of biocomposite of bovine bone-based hydroxyapatite poly(lactic acid)-maleic anhydride
Abstract
Human bone is a composite material of hydroxyapatite (HA) and collagen. HA (Ca10(PO4)6(OH)2) is a biomaterial with the calcium to phosphorus ratio being similar to the natural bone composition. In this study, composite materials were prepared by using poly(lactic acid) (PLA) as a polymer matrix, maleic anhydride (MAH) as a compatibilizer, and natural HA extracted from cow bone (BHA) as a suitable mechanical support filler with positive surface properties. Composites with varying HA (10-30 wt. %), PLA, and with or without MAH (0.5–8 wt. %) were prepared by a thermal decomposition method at 900 ℃. In comparison to commercial HA (CHA), the effect of the PLA and MAH contribution on morphological, thermal, and mechanical properties of BHA were analyzed by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and tensile strength measurements. As per the results, the HA30/PLA/4MAH composite with 30 wt. % HA, 66 wt. % PLA and 4 wt. % MAH offer the maximum mean tensile strength of 307.71 MPa. The overall results confirm the contribution of MAH compatibilizer in HA/PLA/MAH composite materials for bone tissue engineering from a mechanical point of view.
期刊介绍:
The Journal of National Science Foundation of Sri Lanka (JNSF) publishes the results of research in Science and Technology. The journal is released four times a year, in March, June, September and December. This journal contains Research Articles, Reviews, Research Communications and Correspondences.
Manuscripts submitted to the journal are accepted on the understanding that they will be reviewed prior to acceptance and that they have not been submitted for publication elsewhere.